PRE2023 IDENTIFICACION DE REDES GENETICAS DE LA RESILIENCIA Y EL ENVEJECIMIENTO SALUDABLE CON UN ENFOQUE INCLUSIVO DE GENERO (RESILIENCIA)(PID2022-136859NB-I00)

The heterogeneity of healthy ageing is a multifaceted phenomenon influenced by genetics, gender, environmental exposures, and the cumulative effects of past experiences and diseases. In a significant portion of the elderly population, chronological age does not accurately predict or gauge their state of healthy ageing. Additionally, many cancer survivors and individuals recovering from COVID-19 face an elevated risk of accelerated ageing, characterized by frailty, while others display remarkable resilience. Similarly, juvenile organisms exhibit impressive resilience, but the associated costs of such resilience remain largely uncharted. In our RESILIENCE proposal, we harness the power of Drosophila melanogaster's population genomics, advanced circuit tools, and cutting-edge single-cell profiling techniques across multiple organs to comprehensively investigate resilience and its relationship with cancer. Our primary objective is to show how juvenile organisms compensate for disruptions and restore their optimal size. We also aim to uncover the genetic variations that underlie the diverse capacities for resilience and healthy ageing among individuals. By undertaking this research, we aspire to deepen our understanding of the intricate mechanisms behind resilience and its connection to ageing and cancer. Ultimately, our findings could pave the way for innovative strategies to enhance healthy ageing and resilience in individuals facing various health challenges.