PRE2023-Chromatin and Epigenetics in Yeast-PID2022-141321OA-I00

Histone Post-Translational Modifications (PTMs) regulate chromatin functions. Misregulation of histone PTMs and their regulators is associated with human diseases. Hundreds of histone PTMs have been identified in the eukaryotic cell. A small subset of them are very well characterized from model organisms to human cells, however, the function of many others and how they are regulated in a context-specific manner remains a mystery. Until now, systematic functional studies were not possible due to methodological limitations. We are going to tackle this question using a new approach based on reverse genetics, chemical genomics and computational analysis using S.cerevisiae as a model organism. Are you interested in joining our group?