[FPU2019] Desarrollo de nuestro software: difracción de electrones

Structural Biology provides eyes to the life sciences. Thus, crystallography and more recently cryo-electron microscopy, provide conclusive information down to the atomic level allowing to understand all the information around a question in a 3D frame.In the Crystallographic Methods group, we develop computational methods, which we implement in our software ARCIMBOLDO.

Our current projects target challenging cases at low resolution and at the interface between X-ray and electron diffraction through the use of fragments, as a means to capture and enforce experimental knowledge. Currently, we are seeking a Ph.D. student to work on the use of fragments from cryoEM experimental maps for the determination of microED structures. We have established proof of principle for this idea: the superior performance of the expression of electron scattering through the use of experimental maps to the theoretically calculated scattering. Its practical implementation and use to solve structural problems in organic chemistry and biology requires the development of tools within our programs.

We can offer exciting research in an interdisciplinary environment, international experience through participation in meetings and specialised courses, and research stays with our collaborators at the University of Cambridge. Ideal conditions for the development of skills in scientific computing, statistics, structural biology and complementary skills, as well as visibility of the work done and improvement of career prospects through opportunities for training and development.
We are seeking committed students (computing sciences, mathematics, physics, chemistry...) with drive, scientific curiosity and an interest in state of the art programming.
An FPI fellowship is also available.