The main goal of the Glycosystems Laboratory is the study in detail of the biologically relevant recognition processes involving carbohydrates, with the aim to intervene on these processes. In particular, the Glycosystems laboratory is focused on the synthesis of carbohydrates, glycoconjugates, and carbohydrate multivalent systems, the study of these entities at the structural level using computational and Nuclear Magnetic Resonance (NMR) techniques, and the analysis of the interactions of these carbohydrate systems with their corresponding receptors.

The QUIMERA Group emerged from the Organometallic Chemistry and Homogeneous Catalysis Group founded by Prof. Ernesto Carmona in the Department of Inorganic Chemistry in the Universidad de Sevilla at the beginning of the 80's. The group moved to the Instituto de Investigaciones Químicas in 1996, when this research institute was created. Since then this Group has worked on several research lines in Organometallic Chemistry and Homogeneous Catalysis.

Study of the regulation of the activity of the AMPK complex and the pathophysiological basis of the epilepsy of the Lafora type

We are interested in the structural and functional relationships established between proteins and complexes of biomedical interest with a special emphasis on cancer and gene expression control. Ribosome biosynthesis

Since his isolation and characterization of the first human oncogene ( H-ras), Dr Santos¿ scientific career has evolved in close temporal sync with the development of Molecular Oncology. Research in his group has always focused on the study of the structure, function and regulation of Ras family members. Current research is centered on the mechanisms regulating activation of Ras proteins by their specific upstream GEF regulators in physiological and pathological processes such as cancer.

The increased complexity of organisms in evolution requires new layers of regulatory mechanisms. We have identified a human chromatin kinase, VRK1 that plays a complex regulatory role in human biology, and have become the reference group. VRK1 forms complexes with transcription factors such as p53, Sox2, CREB or ATF2 regulating gene transcription, and is critical for entry in cell cycle and proliferation. In cancer, VRK1 is a driver gene associated with poorer prognosis. VRK1 regulates histones chromatin remodeling and its associated epigenetic marks.

Dr. JAVIER DE LAS RIVAS (MSc, PhD, Investigador Científico CSIC, PI at the IMBCC). His group works on 2 main research areas: (i) Development and application of BIOINFORMATICS and COMPUTATIONAL BIOLOGY methods for "omics" data analysis, focusing on the integration of genomic, transcriptomic and proteomic data. All in the field of FUNCTIONAL GENOMICS for: gene expression profiling (pcRNAs and ncRNAs), identification of gene signatures and causal/driver genes, with special interest on "cancer studies" over human samples derived from clinical cohorts.

The research group focuses on the structure-function relationships of a diversity of proteins and macromolecular complexes directly involved in pathological processes. In particular, viral proteins and protein-complexes involved in RNA replication, viral particles and large macromolecular assemblies.

Theoretical studies of mesoscopic systems consisting of metals, ferrmomagnets, superconductors, semiconductors, cold atoms, organic materials and topological insulators, with emphasis in electronic transport (charge, spin, heat) and applications for nano electronics, spintronics and caloritronics.