MOLECULAR TARGETS IN HEALTH AND CANCER, a focus in PIP3 mediator. We study the molecular mechanisms that control physiological cell behavior and cancer, in particular the function of the PIP3 mediator, a molecule necessary for cell survival, division and migration. The aim is to define new therapeutic avenues for lung squamous cell cancer. 1) ACTION OF PI3-KINASE BETA ON STEM CELLS. We study how this enzyme that generates PIP3 in the nucleus regulates stem (and cancer stem) cell homeostasis. 2) REGULATION OF PTEN PHOSPHATASE.

Chemokines and their receptors are proteins involved in homeostasis of the immune system and inflammatory responses that are also involved in growth control, tumor progression and metastasis. The chemokine receptor CCR9, which directs the differentiation of T cells and their migration to the intestine, is overexpressed in certain tumors. Our group is investigating whether CCR9 could be considered as a new target for anti-tumor therapy. We are analyzing whether CCR9-specific monoclonal antibodies, generated in our laboratory, inhibit the growth of human tumors in xenogeneic animal models.

Design, development and biochemical, physico-chemical and nutritional assessment of value-added cereal-based goods. Research is tackled by means of a basic approach for chemically understanding the functionality of cereal constituents in complex matrices. The fundamental information is focused/oriented to the achievement of end cereal products easily transferred and exploited by the related industry. This integrated global approach is devoted either to generate basic knowledge or to transfer obtained results efficiently to the industry.

The ATMA group was created in 2009 by initiative of Dr. Navarro García after having launched, some years before, a Permanent Seminar of the same name. The group’s activities have been focused on creating a space for discussion that will encourage unprecedented research activities in the field of water from multiple perspectives and scopes. With all that it has been attempted to leak beyond theme barriers in order to pursue crossed-line researches.

This research group focusses on the philological analysis, study and interpretation of Greek and Latin texts from the Antiquity to the Early Modern period, in two main areas: 1. Greek Philology and Lexicography, and 2. Latin Philology and Biblical Studies. Reference works (critical editions, translations, commentaries, dictionaries, bibliographies) together with partial studies on linguistics, lexicography, textual criticism, epigraphy, literature, classical reception, etc. form its main scientific output.

The group’s research focuses on Earth surface changes and the underlying geological processes with the aim of anticipating impacts and to propose adaption strategies to diminish the socio-economic losses. The impacts of climate variability, geological processes, and the human effects on the territory (e.g.

The aim of the paleoanthropology group is the analysis of human evolution and development, in their different levels of organization, based on the analysis of fossil remains. The main objectives are specially focused on the morphological evolution, histological organization of hard tissues and behavioural evolution. As remarkable facilities, the group has a fully functional 3D Morphometrics Lab and Experimental Taphonomy Lab.

The research of the group focuses on the study of the Paleontological Record of continental vertebrates, with special emphasis on the description of the patterns and the analysis of the processes involved in the evolution of mammals and Cenozoic paleoenvironments, integrating different methodological approaches and scientific disciplines.

Our group studies the molecular mechanisms that operate on neural networks and modulate the efficiency of synaptic contacts and focuses its activity on the elucidation of the cellular and molecular mechanisms that determine the efficiency of calcium-mediated signaling and calmodulin in the framework of short and long term synaptic plasticity

Ca2+ entry in mitochondria through the Ca2+ uniporter (CaU) is important in cell Ca2+ signaling, but its persistence in mitochondria is associated with mitochondrial dysfunction and cell death. We are interested in the study of systems for Ca2+ signaling in mitochondria that do not require Ca2+ entry in the organelle, the mitochondrial carriers of aspartate-glutamate carriers (AGC) aralar and citrin, and of ATP-Mg/Pi, or Short CaMCs (SCaMCs).