A

The focus of our research in the last years has been on the molecular motors involved in pilus biogenesis and substrate transport in bacterial Type IV Secretion Systems. These motors use the energy from ATP hydrolysis to perform their functions. The final goal of our studies is to characterize the molecular mechanisms involved in this process

Our research group focuses on understanding the interplay between genome organization and gene function. We employ cutting-edge techniques such as super-resolution microscopy and we develop tools to investigate chromatin topology and its impact on cellular processes like transcription, as well as on differentiation and disease.

Despite advances in cancer research, chemotherapy (CT) and radiotherapy (RT) remain the conventional treatments for many tumors. It is estimated that up to 50% of cancer patients are treated with RT and cisplatin-based CT is administered to 10-20% of all cancer patients. This is the case of head and neck squamous cell carcinomas (HNSCC) which arises from the epithelial cells of the oral cavity, pharynx or larynx, and whose survival rate, around 50%, has not improved in the last 30 years. Cisplatin-based chemoradiotherapy (CRT) is the standard treatment of choice for this type of tumor.

Biology and control of parasitic plants of agricultural importance

Our group is interested in the study of subcellular architecture and in exploring the structural alterations that occur in pathological conditions in neurodegenerative diseases, with a special focus on Huntington's Disease as a model. Our hypothesis is that the maintenance of subcellular architecture is essential to preserve cellular homeostasis.

BIOGEO is a CSIC research group dedicated to studying the interactions between living organisms and their environment, with a particular emphasis on how global change and extreme environmental conditions impact ecosystem structure, diversity, functioning, and biogeochemical fluxes. Our mission is to uncover the mechanisms governing biogeochemical processes in aquatic and terrestrial ecosystems through a multiscalar approach (from micro to global scales, including the whole-ecosystem level) and a multitemporal perspective (ranging from minutes to millennia), with special focus on long-term eco