Synthesis and characterisation of electroactive materials and components for applications in energy, environment and biomedicine, including: Design, synthesis, preparation and characterisation of materials for electrodes and electrolytes for PEMFC (proton exchange membrane fuel cells), AEMFC (alkaline anion exchange membrane fuel cells) , SOFC (solid oxide fuel cells) y PCFC (protonic ceramic fuel cells) as well as ceramic gas-separation membranes and oxide-based electorlysers (SOEC, solid oxide electrolyser cells and PCEC, protonic ceramic electrolyser cells). Design and processing of compone

Proposal and evaluation of building systems, facilities and habitability conditions in building

The Research Group is working since 2000 under two Principal Researchers (Moisés Frías y M. Isabel Sánchez de Rojas) although, considering the requirements of this application, the responsibility has been assigned for alternating periods. The main activities developed by this research group are: 1. Recycling of materials, searching for adequate applications taking into account their characteristics, 2. Valorization of by-products in new and innovative materials and 3.

Our research has focused on understanding the processes of morphogenesis and neurodegeneration in the central nervous system (CNS) of vertebrates. We aim to unravel the intricate mechanisms that govern the development and organization of the CNS, as well as the factors that contribute to its dysfunction and degeneration in neurodegenerative diseases.

Using mouse models involving gene modifications such as transgenics, knock-ins, and knockouts, we aim to investigate cellular plasticity within the hematopoietic system. We explore how this plasticity is regulated during both physiological conditions (development) and pathological states (tumorigenesis). Through this research, we aim to enhance our understanding of the molecular and cellular underpinnings of diseases and potentially develop novel therapies.

Glycosylation is a complex post-translational modification that generates diverse glycans, contributing to the functional diversity of proteins. Our group has focused on analyzing the N-glycome using a novel platform to study disease markers. We've collected well-characterized samples from Chagas disease, visceral leishmaniasis, and neurocysticercosis. By analyzing individual glycomic profiles, we've identified markers of treatment efficacy and disease progression.

Our group has demonstrated experience in the functional characterization of surface proteins on tumour, leukocytic and endothelial cells, that have implication in the processes of adhesion, migration, angiogenesis and tumoral dissemination.

Our interest is the identification of the molecular regulators that control the physiological and pathological development of T and non-T (mainly dendritic) cells in the human thymus. Using loss and gain of function genetic approaches, functional assays and in vivo models of hematopoietic reconstitution in humanized mice, we have focused on the Notch1 signaling pathway, analyzing the spatio-temporal regulation of its ligands in the thymus and its role in the physiology of intrathymic T-cell development.

We are interested in understanding how viruses evade the host immune response. We are characterizing herpesvirus and poxvirus proteins that interact with interferons, cytokines or chemokines, and modulate their activity. The contribution of viral cytokine receptors to pathogenesis is being addressed in mouse models of infection.

Our group works in different aspects of the molecular mechanisms mediating animal viruses pathogenesis. The information obtained is being used for the development of new antiviral strategies.