Study of the mechanisms involved in the polarised traffic of MVBs/lytic granules and their role in the secretion of exosomes by T lymphocytes during the processes of cytotoxicity and activation-induced cell death. RESEARCHERID: http://www.researcherid.com/rid/I-4812-2013 ORCID: http://orcid.org/0000-0002-7701-1002 RESEARCHGate: https://www.researchgate.net/profile/Manuel_Izquierdo2 Google Scholar: https://scholar.google.co.uk/citations?user=7z0u7UMAAAAJ&hl=en Publons:https://publons.com/researcher/1737373/manuel-izquierdo/

Role of the Epithelial to Mesenchymal Transition (EMT) of Mesothelial cells in Peritoneal Fibrosis Induced by Dialysis and Surgical Injuries. In addition, We wll Study the Role of Mesothelial EMT in the Generation of Carcinoma Associated Fibroblasts (CAFs) during Peritoneal Metastasis: We Propose EMT as a Disease Biomarker and as a Therapeutic Traget.

Cells respond to ionizing radiation (IR) in various ways, from the activation of survival pathways, to the induction of apoptosis that will eventually eliminate damaged cells, which is what radiotherapy is based on. The type of cellular response to IR depends largely on the cell type that is affected. Thus, there are cells that have greater resistance to radiation than others. A high degree of radio-resistance of the cell type from which tumor growth originates might be one of the underlying causes of the radio-resistance of the tumors derived from that cell type.

Using mouse models involving gene modifications such as transgenics, knock-ins, and knockouts, we aim to investigate cellular plasticity within the hematopoietic system. We explore how this plasticity is regulated during both physiological conditions (development) and pathological states (tumorigenesis). Through this research, we aim to enhance our understanding of the molecular and cellular underpinnings of diseases and potentially develop novel therapies.

Study of diseases associated with disruption of actin filaments. The assembly and disassembly of filamentous actin structures provides a driving force of dynamic processes such as cell motility and growth cone and tumor invasion, and therefore require special control and precise temporal. The reorganization of the actin cytoskeleton is regulated by actin-binding proteins such as WASP (Wiskott Aldrich syndrome protein) and WIP (WASP interacting protein). WIP stabilizes actin filaments and regulates the location and WASP degradation.

The research group's main objective is to deepen the knowledge about the molecular and structural biology of Birnaviridae family members, as well as developing new approaches to prevent birnavirus-borne diseases. Our work involves the use of a wide variety of techniques of virology, molecular genetics, biochemistry, structural and cell biology as well as an intense collaboration with other research groups. The knowledge generated by our group has contributed significantly to solving the birnavirus particle structure and to decipher the virus assembly pathway.

Role of cell type specific transcription factors on the development of neuronal circuits in the mammalian cerebral cortex. Implications in mental disease.

Functional analysis of transcriptional repressor DREAM

Our laboratory is focused on the study of pathogenic human viral infections. Our studies are centered at understanding the molecular basis of viral pathogenesis as well as on identifying novel molecular targets for antiviral therapy. The final aim of our studies is to propose new therapeutic approaches for antiviral treatment as well as for reversion of virus-induced pathogenesis. We believe that determining the cellular and molecular mechanisms by which the virus replicates will provide new opportunities in the fight for clinically relevant human pathogens.

Our group is interested in the molecular basis of replication, transcription, and virus-host interactions of human respiratory coronaviruses (CoVs) using the severe and acute respiratory syndrome virus (SARS-CoV) and the Middle East respiratory syndrome CoV (MERS-CoV) as models. The impact of the infection by these viruses on the host, and the identification of signaling pathways modified by their viruses, are being studied in order to control disease.