Cellular plasticity in development and cancer

Using mouse models involving gene modifications such as transgenics, knock-ins, and knockouts, we aim to investigate cellular plasticity within the hematopoietic system. We explore how this plasticity is regulated during both physiological conditions (development) and pathological states (tumorigenesis). Through this research, we aim to enhance our understanding of the molecular and cellular underpinnings of diseases and potentially develop novel therapies. Additionally, uncovering the latent potential of differentiated cells and reprogramming them into progenitors holds significance for regenerative medicine.