The research activity of this group encompasses developing machine learning techniques, from case-based learning and reasoning to probabilistic learning, and their application. In particular to health, bioinformatics, social networks, music, robotics, and multiagent systems

Our research group contributes in development of theoretical approaches, far beyond simplified models, and the design of specific computational tools to address efficiently real problems of physicochemical interest in the field that links science to technology and innovation. The main goal is the detailed understanding of a variety of molecular processes through quantum dynamics simulations. Our investigation focuses on the study of reactive collisions, large helium clusters doped with impurities, quantum molecular processes in nanoconfined systems and hydration effects in aqueous solutions.

QUINFOG, a group in the intersection between MATTER and SOCIETY due to our work in information technologies, is one of CSIC's international referents in the field of quantum technologies. The group works on fundamental, applied and industry oriented research: from quantum information to the design of hardware for quantum technologies and its applications in quantum computing (in collaboration with companies such as BBVA, GMV, or our startup Inspiration-Q), including the exploration of industrial applications.

The posttranslational modification of proteins is a key mechanism for the regulation of their activity by biological mediators, including lipids and reactive species, drugs and toxins.

The main goal of the ‘Structural Biology of Host-Pathogen Interactions’ group is the study of protein-protein and protein-small molecule interactions that vehicle the communication between the human host and the microbiota and the complement system and bacterial pathogens. To this end we use methods that range from recombinant protein and protein complex production technologies to X-ray diffraction and biochemical and biophysical characterization methods.

Our aim is to provide knowledge-based insights and novel tools for managing arthropods of agricultural and medical relevance. The multidisciplinary composition of the group (physiology, molecular biology, environmental biology and theoretical biology) allows a holistic approach for the implementation of Integrated Pest Management strategies that enable the establishment of more profitable and sustainable production systems, a key issue to increase food security, environmental quality and public health.

Plant virus diseases in commercial crops seriously affect the yield and quality of the food on which we depend. The understanding at the molecular level of interactions between factors from the plant, virus and transmission vector that determine the severity of disease outbreaks is crucial to the design of biotechnology strategies that attenuate their effects. Our group studies them by a combined genomic, proteomic and functional approach.

Adult stem cells, or tissue-specific stem cells maintain the tissue homostasis during the organism's life. We aim to understand the biology of these cells and their relationship with cancer stem cells (CSC). Using different celular models including mammary gland, mesenchymal stem cells, neuronal cells and immune cells we hace demonstrated the plasticity of the stem cells and their relationship with the CSC. The last years we have analyzxed the effect of monoclonal antibodies against meural stem cells and early progenitos in tissue regeneration and the treatment of glioblastomas.

An important part of our studies is focused on the characterization of molecular mechanisms involved in the regulation of lymphocyte migration and differentiation. On the other hand, we are identifying mechanisms of resistance to chemotherapy of melanoma and multiple myeloma cells.

Our work is focused on global regulation of gene expression and on plasmid-mediated horizontal gene transfer, two processes that play a key role in the adaptation of bacteria to specific niches of their eukaryotic hosts. We work with Streptococcus pneumoniae and Enterococcus faecalis, two human commensal bacteria that can become pathogenic under certain circumstances (opportunistic bacteria). Both Gram-positive bacteria can cause serious infections in individuals with a weak immune system and are a leading cause of hospital-acquired infections.