The research group on Distributed Computing on Grids develops its work in the development of distributed computing architectures at pan-European level: federated identity systems for user authentication, advanced software for cloud environments, and data management in distributed infrastructures. The group puts special emphasis on the applicability to scientific use cases. In recent years the support has been concentrated especially in the areas of Particle Physics, Nuclear Fusion, Materials and Environmental Sciences.

Development of the Spinal Cord in health and disease; The role of extracellular signals and the genetic networks that control cell numbers, cell identity and cell shape changes during the embryonic development of the neural tube.

The group STUDIES cellular and molecular mechanisms controlling the proliferative and differentiative potentials of the neural precursors in the developing central nervous system. Our GOAL is to understand the basic processes that sustain neurogenesis in the brain and, particularly in the neocortex, and the pathology underlying congenital brain growth defects (microcephaly and macrocephaly) and other developmental disorders such as intellectual disability and autism.

The research group focuses on the structure-function relationships of a diversity of proteins and macromolecular complexes directly involved in pathological processes. In particular, viral proteins and protein-complexes involved in RNA replication, viral particles and large macromolecular assemblies.

The work carried out in the lab is centered on the analysis of proteins, mainly proteases - including integral membrane proteases-, their zymogens, and their complexes with small-molecule and protein inhibitors at the molecular level. Another line of research deals with bacterial virulence factors and antibiotic resistance mechanisms. Employed techniques include molecular biology, biochemistry, and X-ray crystallography. The lab is fully furnished with state-of-the-art equipment, enabling us to carry out cutting-edge science projects.

The goal of our group is to understand the structural basis of disorders associated with alterations of mitochondrial DNA regulatory proteins. Likewise, we are interested in proteins essential for pathogen viability and virulence. Understanding the molecular basis of diseases is a preliminary stage for target-based rational drug design aimed at therapy and cure. In the lab, we produce the proteins of interest and analyze them by X-ray crystallography.

Chromatin regulation of human and viral gene expression

We are interested in factors and mechanisms involved in the formation and maintenance of chromatin domains and their implication in cell differentiation and development. We ask how interactions between distant sites in the genome are set up, maintained and controlled, and what are the consequences of genome organization inside the nucleus in gene expression. In particular, we study the role of chromatin architectural proteins in alternative promoter selection, response to stimuli and cell-type specific regulation of gene expression.

NANOMOL is a large and interdisciplinary research group with a wide expertise and recognized excellence in the synthesis, processing, characterization, and physico-chemical studies of molecular and polymeric functional materials. We aim to generate new knowledge on the nanostructuring of molecular materials in order to improve the properties of products manufactured in diverse economical sectors, such as electronic, pharmaceutical, and biomedicine.

Synthesis of Electroactive materials and control of their properties and microstructure by electrochemical doping and electrodeposition in various electrode geometries. Aplications in Energy and Bioelectrodes for functional electroestimulation and tissue repair in the central nervous system. Derived from shared Solid state chemistry group that contributed it to crreate and even directed. The use of soft synthesis methods including electrochemical procedures of doping and crystallzation from precursors, allows to obtain new materials.