Structural Biology of Mitochondrial Macromolecules and Pathogens - Structural MitoLab

The goal of our group is to understand the structural basis of disorders associated with alterations of mitochondrial DNA regulatory proteins. Likewise, we are interested in proteins essential for pathogen viability and virulence. Understanding the molecular basis of diseases is a preliminary stage for target-based rational drug design aimed at therapy and cure. In the lab, we produce the proteins of interest and analyze them by X-ray crystallography. If necessary, we include additional techniques such as FRET, electron microscopy and SAXS in collaboration with other groups to disclose the functional mechanism of proteins with a broad, interdisciplinary approach.