Legume derived nutraceuticals as radiosensitizing agents for tumor cells
Natural nutraceutical to promote the prevention of the cancer stem cells (CSCs) phenotype acquisition at the origin of tumor regrowth, metastasis and relapse.
New Cas9 nucleases with unique characteristics for CRISPR-Cas genetic editing
New marine-origin Cas9 nucleases for genetic editing using the CRISPR-Cas system, with applications ranging from gene therapy to the improvement of plant and animal organisms.
New high-performance catalyst for multi-cycle fixed-bed steam reforming of glycerol
Novel nickel-based catalyst that offers long-lasting catalytic activity under high temperature exposure and high efficiency for multi-cycle glycerol reforming processes.
Biomarker for diagnosis and prognosis of Multiple Sclerosis
Analysis of TAF1 isoforms in blood and cerebrospinal fluid of controls and individuals with Multiple Sclerosis.
Rapid decontamination and disinfection of wastewater
Supported photocatalyst based on titanium oxide (TiO2) that allows remediation of pesticides in half the time than commercial ones. In addition, it is effective for the elimination of microorganisms. It is therefore ideal for the decontamination and disinfection of aqueous effluents.
Early diagnosis of Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative disordersenerativos
An in vitro fluorescent method for early detection of Amyotrophic Lateral Sclerosis (ALS) and other TDP-43 related proteinopathies, such as Fronto Temporal Lobar Degeneration (FTLD), based on detection of pathological aggregates of TDP-43 present in cerebrospinal fluid.
Identification of therapeutic candidates for Congenital Central Hypoventilation Syndrome (CCHS)
An in vitro screening method by NMR spectroscopy of potential therapeutic compounds for Congenital Central Hypoventilation Syndrome (CCHS). The method is based in the identification of active agents that inhibit secondary structure changes in PHOX2B transcription factor.
Peptides for the treatment of cardiac diseases
Novel peptide-based compounds for the treatment of cardiovascular diseases, including ventricular arrhythmias in patients with heart failure and hereditary syndromes characterized by reduced function of sodium or potassium ion channels.
Compounds for the treatment of canine Leishmaniosis
New family of compounds with demonstrated in vitro efficacy against intracellular parasites responsible for leishmaniasis and American trypanosomiasis or Chagas disease. Pharmacokinetic and toxicity studies have been conducted in rats, as well as preliminary efficacy studies in a murine model.
Adjustable cutting knife with protection for trimming hides for both tanning and taxidermy
Enhanced knife that enables customizable thinning of hides during the tanning process, offering both protection and adjustable thickness. It is simple to use, features no moving electrical parts, and is highly safe for the user.