Molecular basis of chemo- and radio-resistance in tumors

Our group is interested in studying how cell signalling (e.g. MAPK, AKT) can affect the malignant transformation process. To this end, we have developed several lines of research including chemical and genetic approaches applied to in vitro models of cancer cell lines and in vivo mouse models. We are currently focusing on the study of the role of MAPK-dependent signalling in human sarcoma, a pathology with a high incidence in childhood. Using an experimental mouse model based on chemical carcinogenesis, we hope to clarify the role of MAPKs in the development of soft tissue sarcomas. We also studied the role of cell signalling in the response of cancer to chemotherapy and in response to radiotherapy. Our study covers both conventional chemotherapy and new compounds used in targeted therapy