Matrix Metalloproteinases in Angiogenesis and Inflammation

Our group is interested in elucidating the cellular principles and molecular mechanisms that govern vascular and immune responses during inflammation and how these can contribute to tissue repair. We focus on the actions of membrane-type matrix metalloproteinases (MT-MMPs), a subfamily of proteases that can modify dynamically the extracellular matrix and the activity of soluble and membrane proteins, and particularly in their impact on the behavior of endothelial and smooth muscle cells, and of monocytes/macrophages. We have recently recognized that MT-MMPs participate in blood flow-regulated vascular network reshaping, vessel wall mechanics, and intravascular crawling of patrolling monocytes, a subset in charge of surveying endothelial integrity and combating foreign agents. Our current research lines will allow identifying targets to improve tissue repair and ameliorate disease.