Functional Epi-Genomics of Aging and Alzheimer's Disease

Our laboratory investigates the molecular underpinnings of age-related cognitive decline and neurodegeneration, with a particular interest in Alzheimer’s disease (AD). We hypothesize that genetics, epigenetics, and the interaction of both – “neuro-epi-genetics” –, have long-lasting effects on brain function. To tackle this hypothesis, we use mouse models and human samples, and combine molecular and behavioral neuroscience with state-of-the-art single-cell, next generation sequencing (NGS), bioinformatic tools and epi-genetic editing. Our ultimate goal is to better understand age-related brain malfunctioning and to identify new biomarkers and targets to further develop current dementia-related therapies.