Cellular and Molecular Basis of Alzheimer's disease and other dementias

Our lab is interested in mechanisms that cause cell death in disorders such as Alzheimer's disease, frontotemporal dementia and amyotrophic lateral sclerosis. The work focuses on cell cycle dysfunction, apoptosis, mitochondrial impairment, oxidative damage and proteostasis, using in vivo models of neurodegeneration and in vitro culture of cells, including peripheral cells from patients.