Bioactive Lipids and Lipidomics

Numerous signal transduction processes involve lipids as signaling molecules. Many of these molecules are generated by phospholipases, enzymes which cleave ester bonds within membrane phospholipids. Cells contain multiple phospholipase forms. Our goal is to understand the cellular regulation of these phospholipases under pro- and anti-inflammatory conditions. In our laboratory we combine a range of chemical, biochemical, pharmacological, and molecular cell biology techniques to study lipid metabolism and signaling in physiology and pathophysiology.