In the past decade, increasing evidence has supported the role of integrated mechanical and chemical signalling networks in controlling cell activity and regulating wound repair. Harnessing mechanotransduction, the ways in which cells convert mechanical stimuli into electrochemical activity, is a growing area of research in skin repair. However, techniques are needed to turn non-invasive stimuli into cellular signals that are tightly controlled in space and time, so as to promote healing in deep tissues. The EU-funded SIROCCO project is exploiting 'magnetic switches' to get the job done. Functionalised magnetic nanoparticles will recognise cells of interest and attach to the cell membrane surface. Once attached, they will be activated by magnetic fields, inducing intracellular signalling pathways to enhance wound healing, and potentially even modulate stem cell fate. These magnetic nanoswitches could be exploited in many other pathways and disease processes in future.

ERC-2019-STG