Novel mutant variants of the fusion protein Etanercept with improved TNF neutralizing specificity and therapeutical effect, ameliorating the side effects associated to the clinical use of Etanercept.
A Penicillium chrysogenum strain has been modified to produce high yields of the antifungal protein PdAfpB, enabling the possibility to use this protein in agricultural, food and pharma industries.
Novel Folate Receptor alpha (FRα) binding peptides induce brain cell reprograming and rejuvenation, enhancing cognitive function in aged mice. These unique peptides are able cross the blood-brain barrier and specifically bind to neuroepithelial FRα.
Penicillium strain that produces a highly active antifungal protein (AFP), namely PeAfpA, which is effective against pathogenic and food spoilage fungi. The strain has also been modified to eliminate its antibiotic resistance genes, ensuring its safe use in agriculture, food, and biomedical applications.
A protein domain has been identified with the ability to direct membrane proteins and polypeptides of interest to the zymogen granules of pancreatic cells.
Novel peptide-based compounds for the treatment of cardiovascular diseases, including ventricular arrhythmias in patients with heart failure and hereditary syndromes characterized by reduced function of sodium or potassium ion channels.
Natural nutraceutical to promote the prevention of the cancer stem cells (CSCs) phenotype acquisition at the origin of tumor regrowth, metastasis and relapse.
A recombinant gluten degrading protein that may have application as an agent or food additive for the prevention of gluten-mediated conditions, as well as in the food industry for the manufacturing of gluten-free products.
Effective triple-negative breast cancer treatment based on the modulation of the phenotype of CD206+ tumor associated macrophages by means of a novel peptide-drug-conjugate (PDC) which is able to slow tumor progression and supress lung metastasis.
A conjugate of fatty acids and amino acids has been found to protect neurons and facilitate the removal of protein aggregates that cause the most common neurodegenerative diseases. This opens the possibility of new, more effective and cheap treatments.