Penicillium strain that produces a highly active antifungal protein (AFP), namely PeAfpA, which is effective against pathogenic and food spoilage fungi. The strain has also been modified to eliminate its antibiotic resistance genes, ensuring its safe use in agriculture, food, and biomedical applications.
A protein domain has been identified with the ability to direct membrane proteins and polypeptides of interest to the zymogen granules of pancreatic cells.
New compounds to treat parasitic diseases such as Chagas disease, leishmaniasis and trypanosomiasias. These derivatives act on a new target: G-cuadruplex DNA
Compounds useful as reversible visible-light-regulated antagonists for the localized and temporally restricted activation of beta-adrenoceptors, with application for the treatment of ocular diseases such as glaucoma.
New antiviral compound against HSV-1 and HSV-2 that can be used in combination with other drugs or to treat resistant strains to conventional antivirals.
Selective SGK1 kinase inhibitors, blood-brain barrier-permeable, as drug candidates for the treatment of neurodegenerative diseases (such as Parkinson’s or Alzheimer’s disease) or cardiovascular diseases (such as hypertension).
New family of compounds with demonstrated in vitro efficacy against intracellular parasites responsible for leishmaniasis and American trypanosomiasis or Chagas disease. Pharmacokinetic and toxicity studies have been conducted in rats, as well as preliminary efficacy studies in a murine model.
Novel peptide-based compounds for the treatment of cardiovascular diseases, including ventricular arrhythmias in patients with heart failure and hereditary syndromes characterized by reduced function of sodium or potassium ion channels.
An in vitro screening method by NMR spectroscopy of potential therapeutic compounds for Congenital Central Hypoventilation Syndrome (CCHS). The method is based in the identification of active agents that inhibit secondary structure changes in PHOX2B transcription factor.
Natural nutraceutical to promote the prevention of the cancer stem cells (CSCs) phenotype acquisition at the origin of tumor regrowth, metastasis and relapse.