A recombinant gluten degrading protein that may have application as an agent or food additive for the prevention of gluten-mediated conditions, as well as in the food industry for the manufacturing of gluten-free products.
New family of molecules (low-molecular weight peptides) present in olive oil with blood pressure-reducing activity for hypertensive people
Design of a novel proteolytic set of chimeras (26STACs) directed at the degradation of the ceramide transfer protein CERT-1 by the proteasome, in an E3-independent manner, for its use in the treatment of breast cancer.
Effective triple-negative breast cancer treatment based on the modulation of the phenotype of CD206+ tumor associated macrophages by means of a novel peptide-drug-conjugate (PDC) which is able to slow tumor progression and supress lung metastasis.
New tiourea- and urea-based glycolipids with immunomodulatory activity. The compounds are Mincle agonist and have shown in vitro and in vivo immunostimulant activity. They can be used as vacine adjuvants, in the modulation of the immune response and in the treatment of infectious disease or cancer.
Novel antiviral strategy targeting viral non-essential proteins (NEPs), scarcely prone to adaptive mutations. As a proof of concept, SARS-CoV-2 ORF9b homodimerization inhibitors have been identified that prevents the virus hyperinflammation response.
Andrographolide derivatives for its use as treatment for inflammatory diseases related to cytokine storm.
Polysaccharides, mimics of heparan sulfates present in cells, that are effective in treatment and prevention of viral infections. They act as a decoy trap to prevent the virus from adhering to epithelial cells, thus slowing down the process of infection, and by directly inactivating the viral particles.
A conjugate of fatty acids and amino acids has been found to protect neurons and facilitate the removal of protein aggregates that cause the most common neurodegenerative diseases. This opens the possibility of new, more effective and cheap treatments.
New carbon nanocapsules filled with enriched lithium compounds that can be applied in NCT for cancer treatment