Investigating the molecular role of the TORC1 complex in the regulatory mechanisms coordinating cellular growth and proliferation in eukaryotes

Our group studies the replication of the African swine fever virus (ASFV), one of the most relevant pathogens in the animal health field.

Recent evidence suggests that cerebrovascular diseases and neurodegeneration are closely interconnected. However, the mechanisms by which vascular dysfunction in the brain leads to neuronal damage, and how neurodegeneration may in turn impact vascular health, remain poorly understood.

The Advanced Hydrogeological & Geothermal Systems Research Group (SHGA) studies the hydrogeological dynamics and coupled thermo-chemical regime of shallow and deep aquifers through fully three-dimensional, variable-density, multiphase reactive-transport modelling constrained by georeferenced geochemical databases, high-resolution subsurface temperature time-series, down-hole sensor networks and remote-sensing products. Stable- and radio-isotopic tracers are integrated to resolve groundwater provenance, age distributions and contaminant-flow paths.

The Brain Pathology and Neurodegeneration group is part of the Cajal Platform, whose primary goal is to advance knowledge of the brain’s structural characteristics and their pathological alterations. Specifically, our group is interested in studying the histopathological features and structural alterations of neurons underlying the major human neurological diseases. In particular, we place special emphasis on Alzheimer’s disease, currently recognized as the leading cause of dementia worldwide.