Study of the mechanisms involved in the polarised traffic of MVBs/lytic granules and their role in the secretion of exosomes by T lymphocytes during the processes of cytotoxicity and activation-induced cell death. RESEARCHERID: http://www.researcherid.com/rid/I-4812-2013 ORCID: http://orcid.org/0000-0002-7701-1002 RESEARCHGate: https://www.researchgate.net/profile/Manuel_Izquierdo2 Google Scholar: https://scholar.google.co.uk/citations?user=7z0u7UMAAAAJ&hl=en Publons:https://publons.com/researcher/1737373/manuel-izquierdo/

Our group studies human colon cancer. We use primary cultures of fibroblasts and stem cell-derived organoids established from healthy and tumor tissue of colon cancer patients to investigate the role of the Wnt/beta-catenin pathway, the contribution of the tumor microenvironment, and the antitumor action of vitamin D in this neoplasia.

Study of mechanisms and genes involved in anti-tumour protection in mammals, with a special focus on cellular senescence.

Our work is focussed on the study of the molecular mechanisms that regulate the development, cell differentiation and function of pancreatic islets. We are interested in the mechanisms of transcriptional regulation of gene expression and their implications for the etiopathogenesis of diabetes mellitus and for the regulation of metabolic homeostasis in the organism. In addition, we are interested in the study of the developmental alterations of the central nervous system related with gestational diabetes.

Study of the molecular basis of hearing, pathology of hypoacusis and myelinopathies Hearing loss is one of the most prevalent medical problems. It is estimated that up to 8% of the population of the developed world suffers from it and its index is expected to increase due to aging, noise and other environmental factors. In Spain 200 deep deaf people are born every year and more than one and a half million people suffer chronic hearing problems of greater or lesser degree.

Our group was established in January 2002. We are interested in the origin and conservation of biological diversity. We study the evolution of reproductive strategies and, in particular, the role of post-copulatory sexual selection (sperm competition and cryptic female choice) on male reproductive success. We are interested in how sperm competition has favoured adaptations from the organismal to the molecular level, focusing on mammals and, in particular, on various rodent lineages.

Our research fields are behavioural ecology and conservation biology, and our main current interests are the behavioural and ecological adaptations of strong sexual selection, the evolution of sex ratio, and sexual segregation in species with extreme sexual size dimorphism. We are also interested in knowing the effects of human-induced landscape changes on the behaviour and population dynamics of wild species.

Synthesis, characterization and development of materials for advanced uses for energy production and storage, biomedicine, environment, etc. Functional ceramic materials with energy, photoluminescent and photocatalytic applications are synthesized and characterized chemically. The objective is the development of new ceramic materials with different compositions and morphologies to improve their properties. On the one hand, new carbon-based materials (oxycarbides/graphene) capable of storing electrical energy at room temperature (supercapacitors).

The Group focuses on the development of technical ceramics for applications under demanding operating conditions (mechanical loads, extreme temperatures, corrosive atmospheres or wear conditions), which are common in transport, energy and catalysis fields. This research involves ceramic matrix composites (CMC) and complex 3D structures based on ceramics and carbonaceous materials obtained by direct ink printing. In the case of CMC, the main objective is to enhance the mechanical properties, in particular toughness, while achieving new electrical and thermal functionalities.

The objective of the GlaSS group is the design, processing and characterisation of glasses, glass-ceramics and sol-gel materials, from the structural features to properties (optical, mechanical, chemical, thermal, electrical, etc) and applications. The research is organised in two sub-lines. .