Stress and bacterial evolution

The major interest of the group is to understand the bacterial responses to stress. We specifically study hypermutation and hyperrecombination as bacterial “strategies” to speed adaptation to environmental stresses. One of the models used here is antibiotic stress and the development of antibiotic resistance. Our work is focused on both stable and inducible hypermutation/hyperrecombination in E. coli, P. aeruginosa and M. smegmatis/tuberculosis.