Genomics of Gene Expression

The lab is interested in understanding functional aspects of gene expression at the genome-wide level, across different organisms and in relation to pathological processes. The group has developed statistical methods and software tools that analyze the dynamics aspects transcriptomes, integrate these with other types of molecular data and annotate them functionally, with a special focus on Next Generation Sequencing (NGS) data. The lab has created popular bioinformatics software such Blast2GO, Paintomics, maSigPro, NOISeq, Qualimap, SQANTI, tappAS, with tens of thousands of users world-wide, and has pioneered the methodologies for transcriptome analysis using single-molecule sequencing technologies.