PLASTIMORF leverages cutting-edge structural, orthogonal and translational techniques to unravel mechanisms behind protein structural changes that lead to a prion-like gain-of-function (Structural Biology of Prionoids). We study metamorphic proteins that defy AI-based structural prediction methods. Such proteins adopt alternative conformations in response to specific stimuli, leading to multimerization into biomolecular condensates or amyloid aggregates.

Structural biology group studying proteins involved in RNA cell cycle. We study the structure of RNA binding proteins (RBPs) and their interactions at structural detail using NMR and biophysical techniques (ITC, DLS, MALS, FA) and with other structural techniques (X-ray, CryoEM, SAXS) in close collaboration with other CSIC groups. We study RBPs part of the RNA life cycle during the maturation of mRNPs (Gbp2, Hrb1 Nrd1, Nab3, Hrp1 or CstF64), or regulation of translation and stress response (eIF4G, Pab1, Pub1).