Our group is involved in the identification of relevant genes in root architecture and in arsenic tolerance to develop biotechnological tools for arsenic phytoremediation and nutrient uptake.

Our group is devoted to the structural determination of macromolecular complexes, among them molecular chaperones, proteins that assist the folding of other proteins. We use mainly electron microscopy and image processing techniques, but we combine them with biochemical and molecular biology techniques, to structural and functionaly characterise various molecular chaperones, among them CCT, Hsp90, Hsp70, Hs40 and PFD, and cochaperones like PhLP, Hop, Hip and CHIP. Our group is also interested in the use of single-molecule techniques, in particular optical tweezers, in collaboration with the gr

We work in the field of three-dimensional microscopy, both electron and Soft X-rays microscopy, focusing on the development of new image processing methods for Tomorgraphy. A substantial fraction of our work is devoted to Instruct, the European project in Structural Biology within the ESFRI initiative (European Strategic Forum for Research Infrastructures), being its Image Processing Center (I2PC, for Instruct Image Processing Center)

Studying virus factories as scaffolds for viral replication and morphogenesis. Development of new imaging technologies to study viruses in cells and to visualize macromolecular complexes in their natural environment. New antivirals and drug repurposing.

The overall objective of our group is to understand nanomedicines-mediated molecular and cellular mechanisms in distinct biomedical applications oriented to cancer and autoimmunity treatment, and to use this knowledge to improve nanomedicines functional design for antitumour and autoinmune disease therapies.

The complexity of the B lymphocyte immune response involves changes in cell behavior, switching from highly motile states to stable cell-to-cell interactions (immune synapse), adjustments of the cell mechanical properties (flexibility, stiffness) and cell polarity (MTOC and organelle distribution). Gene mutations or functional alterations in proteins related with these events are frequent in B lymphocyte-pathologies (immunodeficiency, lymphomas), stressing their relevance for B cell function.

Understanding the mechanisms of chemokine signaling and chemokine function with the aim to provide a clearer understanding of how this family of proteins acts, and define new orientations for the treatment of inflammatory, autoimmune and infectious diseases. Our group, using resonance energy transfer tecnologies (FRET, BRET) and advanced microscopy, STED and TIRF , have determined that these receptors form homo- and heterodimers and even oligomers at the cell membrane.

The healthy immune system makes use of a variety of surveillance mechanisms at different stages of lymphoid development to prevent the occurrence and expansion of potentially harmful autoreactive T cell clones. Disruption of these mechanisms may lead to inappropriate activation of T cells and the development of autoimmune and lymphoproliferative diseases [such as multiple sclerosis, rheumatoid arthritis, lupus erythematosus, diabetes and autoimmune lymphoproliferative syndrome (ALPS)].

Estudio de la neurobiologia de la enfermedad de Parkinson y el sistema dopaminérgico. Desarrollo de protocolos de trasplante de neuronas dopaminérgicas derivadas de IPs humanas en modelos animales para su posible traslación a terapias celulares en la Enfermedad de Parkinson