Skip to main content
 
  • Home
  • M.CARMEN VALENZUELA MIRANDA
imagen por defecto

M.CARMEN VALENZUELA MIRANDA

Instituto
INSTITUTO DE INVESTIGACIONES BIOMEDICAS SOLS-MORREALE
Contactar

KCNE4-dependent modulation of Kv1.3 pharmacology

2024 Biochemical Pharmacology
Volume:
226
Initial page:
116368
End page:
-
Authors:
Sastre D;Colomer-Molera M;de Benito-Bueno A;Valenzuela C;Fernandez-Ballester G;Felipe A

Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions

2024 Acta Physiologica
Volume:
240
Initial page:
e14106
End page:
-
Authors:
Serrano-Novillo C;Estadella I;Navarro-Pérez M;Oliveras A;de Benito-Bueno A;Socuéllamos PG;Bosch M;Coronado MJ;Sastre D;Valenzuela C;Soeller C;Felipe A

IQM-22110, a new selective inhibitor of KChIP3 and its electrophysiological effects on Kv4.3, Kv4.3/KChIP3 and Kv4.3/KChIP2 currents

2023 Biophysical Journal
Volume:
122
Initial page:
-
End page:
-
Authors:
Socuéllamos, P.G.;de Benito-Bueno, A.;Ropero, M.;Diez, S.;Elizalde, P.;Bonache, M.A.;Viedma, C.;Martín-Martínez, M.;Gutiérrez-Rodríguez, M.;Valenzuela, C.

Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of Kv1.3 and Kv1.5 channels

2023 Biomedicine and Pharmacotherapy
Volume:
161
Initial page:
-
End page:
-
Authors:
Peraza DA;Povo-Retana A;Mojena M;Garcia-Redondo AB;Aviles P;Bosca L;Valenzuela C.

Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

2023 Pharmacological Research
Volume:
189
Initial page:
-
End page:
-
Authors:
Vera-Zambrano A;Baena-Nuevo M;Rinné S;Villegas-Esguevillas M;Barreira B;Telli G;de Benito-Bueno A;Blázquez JA;Climent B;Pérez-Vizcaino F;Valenzuela C;Decher N;Gonzalez T;Cogolludo A

Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension

2023 Hypertension
Volume:
80
Initial page:
84
End page:
96
Authors:
Díaz Del Campo LS;García-Redondo AB;Rodríguez C;Zaragoza C;Duro-Sánchez S;Palmas F;de Benito-Bueno A;Socuéllamos PG;Peraza DA;Rodrigues-Díez R;Valenzuela C;Dalli J;Salaices M;Briones AM

Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction

2023 Biomedicine and Pharmacotherapy
Volume:
158
Initial page:
114214
End page:
-
Authors:
Paz-García M;Povo-Retana A;Jaen RI;Prieto P;Peraza DA;Zaragoza C;Hernandez-Jimenez M;Pineiro;Regadera J;García-Bermejo ML;Rodríguez-Serrano EM;Sanchez-García S;Moro MA;Lizasoaín I;Delgado C;Valenzuel...et all

IQM-PC332, a Novel DREAM Ligand with Antinociceptive Effect on Peripheral Nerve Injury-Induced Pain

2022 International Journal of Molecular Sciences
Volume:
23
Initial page:
2142
End page:
-
Authors:
Socuéllamos PG;Olivos-Oré LA;Barahona MV;Cercós P;Pérez Pascual M;Arribas-Blázquez M;Naranjo JR;Valenzuela C;Gutiérrez-Rodríguez M;Artalejo AR

Modulation of Kv4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2

2022 International Journal of Molecular Sciences
Volume:
23
Initial page:
-
End page:
-
Authors:
de Benito-Bueno A;Socuéllamos PG;Merinero, YG;Cercos P;Izquierdo C;Daniel-Mozo M;Marín-Olivero I;Perez-Lara A;Gonzalez-Vera JA;Orte A;Albert A;Martin-Martinez M;Gutierrez-Rodriguez M;Valenzuela C

A novel loss of function mutation of the voltage gated potassium channel Kv10.2 involved in epilepsy and autism

2022 Orphanet Journal of Rare Diseases
Volume:
17
Initial page:
-
End page:
-
Authors:
Galán¿Vidal J;Socuéllamos PG;Baena¿Nuevo M;Contreras L;González T;Pérez¿Poyato MS;Valenzuela C;González¿Lamuño D;Gandarillas A

Kv1.5-Kvb1.3 Recycling is PKC-Dependent

2021 International Journal of Molecular Sciences
Volume:
22
Initial page:
1336
End page:
-
Authors:
Macias A;de la Cruz A;Peraza DA;de Benito-Bueno A;Gonzalez T;Valenzuela C

Identification of a critical binding site for local anaesthetics in the side pockets of Kv1 channels

2021 British Journal of Pharmacology
Volume:
178
Initial page:
3034
End page:
3048
Authors:
Kiper AK;Bedoya M;Stalke S;Marzian S;Ramírez D;de la Cruz A;Peraza DA;Vera-Zambrano A;Márquez Montesinos JCE;Arévalo Ramos BA;Rinné S;Gonzalez T;Valenzuela C;Gonzalez W;Decher N...et all

Graphene Particles Interfere with Pro-Inflammatory Polarization of Human Macrophages: Functional and Electrophysiological Evidence

2021 Advanced Biology
Volume:
5
Initial page:
-
End page:
-
Authors:
Povo-Retana A;Mojena M;Boscá A;Pedrós J;Peraza DA;Valenzuela C;Laparra JM;Calle F;Boscá L

Pharmacological approaches for the modulation of the potassium channel KV4.x and KChIPs

2021 International Journal of Molecular Sciences
Volume:
22
Initial page:
1419
End page:
-
Authors:
Cercós P;Peraza DA;de Benito-Bueno A;Socuéllamos PG;Aziz-Nignan A;Arrechaga-Estévez D;Beato E;Peña-Acevedo E;Albert A;González-Vera JA;Rodríguez Y;Martín-Martínez M;Valenzuela C;Gutiérrez-Rodríguez M

Kv1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in angiotensin II-induced hypertension in mice

2021 British Journal of Pharmacology
Volume:
178
Initial page:
1836
End page:
1854
Authors:
Olivencia MA;Martínez-Casales M;Peraza DA;García-Redondo AB;Mondéjar-Parreño G;Hernanz R;Salaices M;Cogolludo A;Pennington MW;Valenzuela C;Briones AM

The unconventional biogenesis of Kv7.1-KCNE1 complexes

2020 Science Advances
Volume:
6
Initial page:
-
End page:
-
Authors:
Oliveras, A.;Serrano-Novillo, C.;Moreno, C.;de la Cruz, A.;Valenzuela, C.;Soeller, C.;Comes, N.;Felipe, A.

Identification of IQM-266, a Novel DREAM Ligand That Modulates Kv4 Currents

2019 Frontiers in Molecular Neuroscience
Volume:
12
Initial page:
1
End page:
-
Authors:
Peraza DA;Cercós P;Miaja P;Merinero YG;Lagartera L;Socuéllamos PG;Izquierdo García C;Sánchez SA;López-Hurtado A;Martín-Martínez M;Olivos-Oré LA;Naranjo JR;Artalejo AR;Gutiérrez-Rodríguez M;Valenzuela...et all

Activation of Kv 7 channels as a novel mechanism for NO/cGMP-induced pulmonary vasodilation

2019 British Journal of Pharmacology
Volume:
176
Initial page:
2131
End page:
2145
Authors:
Mondéjar-Parreño G;Moral-Sanz J;Barreira B;De la Cruz A;Gonzalez T;Callejo M;Esquivel-Ruiz S;Morales-Cano D;Moreno L;Valenzuela C;Perez-Vizcaino F;Cogolludo A

Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment

2019 Scientific Reports
Volume:
9
Initial page:
7260
End page:
-
Authors:
Lopez-Hurtado A;Peraza DA;Cercos P;Lagartera L;Gonzalez P;Dopazo XM;Herranz R;Gonzalez T;Martin-Martinez M;Mellström B;Naranjo JR;Valenzuela C;Gutierrez-Rodriguez M

Differential effect of Androctonus australis hector venom components on macrophage KV channels: electrophysiological characterization

2019 European Biophysics Journal
Volume:
48
Initial page:
1
End page:
13
Authors:
Khemili D;Valenzuela C;Laraba-Djebari F;Hammoudi-Triki D

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence

2017 Journal of Molecular and Cellular Cardiology
Volume:
110
Initial page:
61
End page:
69
Authors:
Moreno C;Oliveras A;Bartolucci C;Muñoz C;de la Cruz A;Peraza DA;Gimeno JR;Martín-Martínez M;Severi S;Felipe A;Lambiase PD;González T;Valenzuela C

Fludarabine Inhibits Kv1.3 Currents in Human B Lymphocytes

2017 Frontiers in Pharmacology
Volume:
8
Initial page:
-
End page:
-
Authors:
De la Cruz A;Vera-Zambrano A;Peraza DA;Valenzuela C;Zapata JM;Perez-Chacon G;Gonzalez T

Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.

2016 JOURNAL OF CLINICAL INVESTIGATION
Volume:
126
Initial page:
627
End page:
638
Authors:
Naranjo JR;Zhang H;Villar D;González P;Dopazo XM;Morón-Oset J;Higueras E;Oliveros JC;Arrabal MD;Prieto A;Cercós P;González T;De la Cruz A;Casado-Vela J;Rábano A;Valenzuela C;Gutierrez-Rodriguez M;Li ...et all

M-channels and n-3 polyunsaturated fatty acids: role in pain and epilepsy

2016 Acta Physiologica
Volume:
218
Initial page:
7
End page:
9
Authors:
Valenzuela, C.

In-depth study of the interaction, sensitivity, and gating modulation by PUFAs on K+ channels; interaction and new targets

2016 Frontiers in Physiology
Volume:
7
Initial page:
-
End page:
-
Authors:
Moreno, C.;de la Cruz, A.;Valenzuela, C.

A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome

2015 Cardiovascular Research
Volume:
107
Initial page:
613
End page:
623
Authors:
Moreno C;Oliveras A;de la Cruz A;Bartolucci C;Muñoz C;Salar E;Gimeno JR;Severi S;Comes N;Felipe A;González T;Lambiase P;Valenzuela C

Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains

2015 Cardiovascular Research
Volume:
105
Initial page:
223
End page:
232
Authors:
Moreno, C.;De La Cruz, A.;Oliveras, A.;Kharche, S.R.;Guizy, M.;Comes, N.;Starý, T.;Ronchi, C.;Rocchetti, M.;Baró, I.;Loussouarn, G.;Zaza, A.;Severi, S.;Felipe, A.;Valenzuela, C....et all

Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.

2015 PLoS ONE
Volume:
10
Initial page:
e0140782
End page:
-
Authors:
Molina-Guijarro JM;García C;Macías A;García-Fernández LF;Moreno C;Reyes F;Martínez-Leal JF;Fernández R;Martínez V;Valenzuela C;Lillo MP;Galmarini CM

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

2014 Arteriosclerosis, Thrombosis, and Vascular Biology
Volume:
34
Initial page:
1522
End page:
1530
Authors:
Oliveras, A.;Roura-Ferrer, M.;Solé, L.;De La Cruz, A.;Prieto, A.;Etxebarria, A.;Manils, J.;Morales-Cano, D.;Condom, E.;Soler, C.;Cogolludo, A.;Valenzuela, C.;Villarroel, A.;Comes, N.;Felipe, A....et all

PKC inhibition results in a Kv 1.5 + Kv ß1.3 pharmacology closer to Kv 1.5 channels.

2014 British Journal of Pharmacology
Volume:
171
Initial page:
4914
End page:
4926
Authors:
Macías A;de la Cruz A;Prieto A;Peraza DA;Tamkun MM;González T;Valenzuela C

Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-a4 in activated murine macrophages: implications in innate immunity

2013 Journal of Immunology
Volume:
191
Initial page:
6136
End page:
6146
Authors:
Moreno C;Prieto P;Macías A;Pimentel-Santillana M;de la Cruz A;Través PG;Boscá L;Valenzuela C

Female gender: risk factor for congenital long QT-related arrhythmias

2012 Cardiovascular Research
Volume:
95
Initial page:
263
End page:
264
Authors:
Valenzuela,C.

Protein Kinase C (PKC) Activity Regulates Functional Effects of Kvß1.3 Subunit on KV1.5 Channels: IDENTIFICATION OF A CARDIAC Kv1.5 CHANNELOSOME.

2012 Journal of Biological Chemistry
Volume:
287
Initial page:
21416
End page:
-
Authors:
David M;Macías A;Moreno C;Prieto A;Martínez-Mármol R;Vicente R;González T;Felipe A;Tamkun MM;Valenzuela C

Stereoselective interactions between local anesthetics and ion channels.

2012 Chirality
Volume:
24
Initial page:
944
End page:
950
Authors:
Valenzuela C;Moreno C;de la Cruz A;Macías A;Prieto A;González T

Effects of n¿3 Polyunsaturated Fatty Acids on Cardiac Ion Channels

2012 Frontiers in Physiology
Volume:
3
Initial page:
245
End page:
-
Authors:
Moreno C;Macías A;Prieto A;de la Cruz A;González T;Valenzuela C

Polyunsaturated fatty acids modify the gating of Kv channels

2012 Frontiers in Pharmacology
Volume:
3 SEP
Initial page:
null
End page:
-
Authors:
Moreno, C.;Macias, A.;Prieto, A.;De La Cruz, A.;Valenzuela, C.

Female gender: Risk factor for congenital long QT-related arrhythmias

2012 Cardiovascular Research
Volume:
95
Initial page:
263
End page:
264
Authors:
Valenzuela, C.

Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries

2011 American Journal of Physiology - Cell Physiology
Volume:
301
Initial page:
C186
End page:
C194
Authors:
Moral-Sanz, J. ; Gonzalez, T. ; Menendez, C. ; David, M. ; Moreno, L. ; Macias, A. ; Cortijo, J. ; Valenzuela, C. ; Perez-Vizcaino, F. ; Cogolludo, A.

Irvalec inserts into the plasma membrane causing rapid loss of integrity and Necrotic Cell Death in Tumor Cells

2011 PLoS ONE
Volume:
6
Initial page:
null
End page:
-
Authors:
Molina-Guijarro, J.M.;Macías, A.;García, C.;Muñoz, E.;García-Fernández, L.F.;David, M.;Núñez, L.;Martínez-Leal, J.F.;Moneo, V.;Cuevas, C.;Lillo, M.P.;Jorge, C.V.;Valenzuela, C.;Galmarini, C.M.

Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels

2010 Biochemical Pharmacology
Volume:
80
Initial page:
858
End page:
866
Authors:
Villalonga, N.;David, M.;Bielanska, J.;González, T.;Parra, D.;Soler, C.;Comes, N.;Valenzuela, C.;Felipe, A.;David M

Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels. Effects on cardiac action potentials

2010 Journal of Molecular and Cellular Cardiology
Volume:
49
Initial page:
984
End page:
992
Authors:
Macías, A.;Moreno, C.;Moral-Sanz, J.;Cogolludo, A.;David, M.;Alemanni, M.;Pérez-Vizcaíno, F.;Zaza, A.;Valenzuela, C.;Gonzalez, T.

Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.

2010 Mini reviews in medicinal chemistry
Volume:
10
Initial page:
635
End page:
642
Authors:
González, T. ; David, M. ; Moreno, C. ; Macías, A. ; Valenzuela, C.

Immunomodulation of voltage-dependent K+ channels in macrophages: Molecular and biophysical consequences

2010 Journal of General Physiology
Volume:
135
Initial page:
135
End page:
147
Authors:
Villalonga, N.;David, M.;Biejanska, J.;Vicente, R.;Comes, N.;Valenzuela, C.;Felipe, A.

Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, α-linolenic acid

2008 Journal of Molecular and Cellular Cardiology
Volume:
44
Initial page:
323
End page:
335
Authors:
Guizy, M.;David, M.;Arias, C.;Zhang, L.;Cofán, M.;Ruiz-Gutiérrez, V.;Ros, E.;Lillo, M.P.;Martens, J.R.;Valenzuela, C.

Differential regulation of Navβ subunits during myogenesis

2008 Biochemical and Biophysical Research Communications
Volume:
368
Initial page:
761
End page:
766
Authors:
David, M.;Martínez-Mármol, R.;Gonzalez, T.;Felipe, A.;Valenzuela, C.

Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation

2008 Biochimica et Biophysica Acta - Molecular Cell Research
Volume:
1783
Initial page:
728
End page:
736
Authors:
Villalonga, N.;Martínez-Mármol, R.;Roura-Ferrer, M.;David, M.;Valenzuela, C.;Soler, C.;Felipe, A.

Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts

2008 American Journal of Physiology - Heart and Circulatory Physiology
Volume:
295
Initial page:
H1414
End page:
H1421
Authors:
Dujardin, K.S. ; Dumotier, B. ; David, M. ; Guizy, M. ; Valenzuela, C. ; Hondeghem, L.M.

Kvβ1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels

2007 Anesthesiology
Volume:
107
Initial page:
641
End page:
651
Authors:
Arias, C. ; Guizy, M. ; David, M. ; Marzian, S. ; González, T. ; Decher, N. ; Valenzuela, C.

Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair

2007 Cardiovascular Research
Volume:
76
Initial page:
430
End page:
441
Authors:
Martínez-Mármol, R.;David, M.;Sanches, R.;Roura-Ferrer, M.;Villalonga, N.;Sorianello, E.;Webb, S.M.;Zorzano, A.;Gumà, A.;Valenzuela, C.;Felipe, A.

The induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation

2006 Biochimica et Biophysica Acta - Molecular Cell Research
Volume:
1763
Initial page:
110
End page:
119
Authors:
Arias, C.;Guizy, M.;Luque-Ortega, J.R.;Guerrero, E.;De La Torre, B.G.;Andreu, D.;Rivas, L.;Valenzuela, C.

{Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels.

2005 American Journal of Physiology - Cell Physiology
Volume:
289
Initial page:
C1251
End page:
C1260
Authors:
Guizy M;Arias C;David M;González T;Valenzuela C

Stereoselective interactions between local anesthetics and cardiac K + channels

2005 Drug Design Reviews Online
Volume:
2
Initial page:
389
End page:
396
Authors:
Guizya, M.;Ariasa, C.;David, M.;Valenzuela, C.

Pharmacology of cardiac potassium channels

2004 Cardiovascular Research
Volume:
62
Initial page:
9
End page:
33
Authors:
Tamargo, J.;Caballero, R.;Gómez, R.;Valenzuela, C.;Delpón, E.

Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current

2004 Cardiovascular Research
Volume:
62
Initial page:
86
End page:
95
Authors:
Caballero, R;Gómez, R;Moreno, I;Nuñez, L;González, T;Arias, C;Guizy, M;Valenzuela, C;Tamargo, J;Delpón, E

Pharmacological electrical remodelling in human atria induced by chronic β-blockade

2003 Cardiovascular Research
Volume:
58
Initial page:
498
End page:
500
Authors:
Valenzuela, C.

Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization

2003 Journal of Pharmacology and Experimental Therapeutics
Volume:
304
Initial page:
862
End page:
873
Authors:
Moreno, I.;Caballero, R.;González, T.;Arias, C.;Valenzuela, C.;Iriepa, I.;Gálvez, E.;Tamargo, J.;Delpón, E.

Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels

2003 Circulation
Volume:
107
Initial page:
889
End page:
895
Authors:
Caballero, R.;Moreno, I.;González, T.;Arias, C.;Valenzuela, C.;Delpón, E.;Tamargo, J.

Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels

2003 Cardiovascular Research
Volume:
57
Initial page:
660
End page:
669
Authors:
Arias, C.;González, T.;Moreno, I.;Caballero, R.;Delpón, E.;Tamargo, J.;Valenzuela, C.

Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: Stereoselective bupivacaine block

2002 British Journal of Pharmacology
Volume:
137
Initial page:
1269
End page:
1279
Authors:
González, T.;Arias, C.;Caballero, R.;Moreno, I.;Delpón, E.;Tamargo, J.;Valenzuela, C.

Assembly with the Kvß1.3 subunit modulates drug block of hKv1.5 channels

2002 Molecular Pharmacology
Volume:
62
Initial page:
1456
End page:
1463
Authors:
González, T.;Navarro-polanco, R.;Arias, C.;Caballero, R.;Moreno, I.;Delpón, E.;Tamargo, J.;Tamkun, M.M.;Valenzuela, C.

Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5)

2002 Cardiovascular Research
Volume:
56
Initial page:
104
End page:
117
Authors:
Caballero, R.;Moreno, I.;González, T.;Valenzuela, C.;Tamargo, J.;Delpón, E.

Bupivacaine effects on hkv1.5 channels are dependent on extracellular pH

2001 British Journal of Pharmacology
Volume:
134
Initial page:
359
End page:
369
Authors:
Longobardo, M.;González, T.;Caballero, R.;Delpón, E.;Tamargo, J.;Valenzuela, C.

Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5)

2001 British Journal of Pharmacology
Volume:
132
Initial page:
385
End page:
392
Authors:
González, T.;Longobardo, M.;Caballero, R.;Delpón, E.;Sinisterra, J.V.;Tamargo, J.;Valenzuela, C.

Effect of bupivacaine and a novel local anesthetic IQB-9302, on human cardiac K+ channels

2001 Journal of Pharmacology and Experimental Therapeutics
Volume:
296
Initial page:
573
End page:
583
Authors:
González, T.;Longobardo, M.;Caballero, R.;Delpón, E.;Tamargo, J.;Valenzuela, C.

Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization

2001 Molecular Pharmacology
Volume:
59
Initial page:
825
End page:
836
Authors:
Caballero, R.;Delpón, E.;Valenzuela, C.;Longobardo, M.;González, T.;Tamargo, J.

Losartan and its metabolite E3174 modify cardiac delayed rectifier K+ currents

2000 Circulation
Volume:
101
Initial page:
1199
End page:
1205
Authors:
Caballero, R.;Delpón, E.;Valenzuela, C.;Longobardo, M.;Tamargo, J.

Effects of a quaternary bupivacaine derivative on delayed rectifier K + currents

2000 British Journal of Pharmacology
Volume:
130
Initial page:
391
End page:
401
Authors:
Longobardo, M.;González, T.;Navarro-Polanco, R.;Caballero, R.;Delpón, E.;Tamargo, J.;Snyders, D.J.;Tamkun, M.M.;Valenzuela, C.

Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac Kv1.5 channels

1999 British Journal of Pharmacology
Volume:
128
Initial page:
1071
End page:
1081
Authors:
Caballero, R.;Valenzuela, C.;Longobardo, M.;Tamargo, J.;Delpón, E.

Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

1999 Cardiovascular Research
Volume:
41
Initial page:
212
End page:
219
Authors:
Franqueza, L.;Valenzuela, C.;Eck, J.;Tamkun, M.M.;Tamargo, J.;Snyders, D.J.

Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5)

1999 Cardiovascular Research
Volume:
42
Initial page:
510
End page:
520
Authors:
Delpón, E.;Caballero, R.;Valenzuela, C.;Longobardo, M.;Snyders, D.;Tamargo, J.

Structural determinants of potency and stereoselective block of hKv1.5 channels induced by local anesthetics

1998 Molecular Pharmacology
Volume:
54
Initial page:
162
End page:
169
Authors:
Longobardo, M.;Delpón, E.;Caballero, R.;Tamargo, J.;Valenzuela, C.

Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels

1998 British Journal of Pharmacology
Volume:
125
Initial page:
969
End page:
978
Authors:
Franqueza, L.;Valenzuela, C.;Delpón, E.;Longobardo, M.;Caballero, R.;Tamargo, J.

Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels

1997 Circulation Research
Volume:
81
Initial page:
1053
End page:
1064
Authors:
Franqueza, L.;Longobardo, M.;Vicente, J.;Delpon, E.;Tamkun, M.M.;Tamargo, J.;Snyders, D.J.;Valenzuela, C.

Electrophysiological effects of CI-980, a tubulin binding agent, on guinea-pig papillary muscles

1997 British Journal of Pharmacology
Volume:
120
Initial page:
187
End page:
192
Authors:
Pérez, O.;Valenzuela, C.;Delpón, E.;Tamargo, J.

Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle

1997 Anesthesiology
Volume:
86
Initial page:
718
End page:
728
Authors:
Valenzuela, C.;Delpón, E.;Franqueza, L.;Gay, P.;Snyders, D.J.;Tamargo, J.

Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5

1997 British Journal of Pharmacology
Volume:
122
Initial page:
796
End page:
798
Authors:
Caballero, R.;Delpón, E.;Valenzuela, C.;Longobardo, M.;Franqueza, L.;Tamargo, J.

Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels

1997 European Journal of Pharmaceutics and Biopharmaceutics
Volume:
326
Initial page:
257
End page:
263
Authors:
Valenzuela, C.;Delpón, E.;Franqueza, L.;Gay, P.;Vicente, J.;Tamargo, J.

Block of human cardiac Kv1.5 channels by loratadine: Voltage-, time- and use-dependent block at concentrations above therapeutic levels

1997 Cardiovascular Research
Volume:
35
Initial page:
341
End page:
350
Authors:
Delpón, E.;Valenzuela, C.;Gay, P.;Franqueza, L.;Snyders, D.J.;Tamargo, J.

Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2

1996 British Journal of Pharmacology
Volume:
117
Initial page:
1293
End page:
1301
Authors:
Delpón, E.;Valenzuela, C.;Pérez, O.;Franqueza, L.;Gay, P.;Snyders, D.J.;Tamargo, J.

Class III antiarrhythmic effects of zatebradine: Time-, state-, use-, and voltage-dependent block of hKv1.5 channels

1996 Circulation
Volume:
94
Initial page:
562
End page:
570
Authors:
Valenzuela, C.;Delpon, E.;Franqueza, L.;Gay, P.;Perez, O.;Tamargo, J.;Snyders, D.J.

Effects of loratadine on a delayed rectifier potassium channel cloned from human heart | Efecto bloqueante de la loratadina en canales de K + cardiacos humanos clonados

1996 Anales de la Real Academia Nacional de Farmacia
Volume:
62
Initial page:
25
End page:
60
Authors:
Delpón, E.;Valenzuela, C.;Franqueza, L.;Gay, P.;Pérez-Vizcaíno, F.;Tamargo, J.

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

1995 Biophysical Journal
Volume:
69
Initial page:
418
End page:
427
Authors:
Valenzuela, C.;Delpon, E.;Tamkun, M.M.;Tamargo, J.;Snyders, D.J.

Antiarrhythmic agents | Farmacos antiarritmicos

1995 Ars Pharmaceutica
Volume:
36
Initial page:
507
End page:
526
Authors:
Valenzuela, C.;Tamargo, J.;Delpon, E.;Perez, O.

Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations

1995 British Journal of Pharmacology
Volume:
115
Initial page:
787
End page:
794
Authors:
Perez, O.;Gay, P.;Franqueza, L.;Carron, R.;Valenzuela, C.;Delpon, E.;Tamargo, J.

Electromechanical effects of zatebradine on isolated guinea pig cardiac preparations

1995 Journal of Cardiovascular Pharmacology
Volume:
26
Initial page:
46
End page:
54
Authors:
Perez, O.;Gay, P.;Franqueza, L.;Carron, R.;Valenzuela, C.;Delpon, E.;Tamargo, J.

On the molecular nature of the lidocaine receptor of cardiac Na+ channels modification of block by alterations in the ¿-subunit III-IV interdomain

1995 Circulation Research
Volume:
77
Initial page:
584
End page:
592
Authors:
Bennett, P.B.;Valenzuela, C.;Chen, L.-Q.;Kallen, R.G.

Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes: Voltage-independent and time-dependent block of the slowly activating component

1995 Circulation Research
Volume:
76
Initial page:
223
End page:
235
Authors:
Delpón, E.;Valenzuela, C.;Pérez, O.;Casis, O.;Tamargo, J.

Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes

1995 Circulation
Volume:
92
Initial page:
3014
End page:
3024
Authors:
Valenzuela, C.;Snyders, D.J.;Bennett, P.B.;Tamargo, J.;Hondeghem, L.M.

Imipramine blocks rapidly activating and delays slowly activating K+ current activation in guinea pig ventricular myocytes

1994 Circulation Research
Volume:
74
Initial page:
687
End page:
699
Authors:
Valenzuela, C.;Sánchez-Chapula, J.;Delpón, E.;Elizalde, A.;Pérez, O.;Tamargo, J.

Gating of cardiac Na+ channels in excised membrane patches after modification by ¿-chymotrypsin

1994 Biophysical Journal
Volume:
67
Initial page:
161
End page:
171
Authors:
Valenzuela, C.;Bennett Jr., P.B.

Class I and II antiarrhythmic actions of prazosin in guinea-pig papillary muscles

1994 British Journal of Pharmacology
Volume:
111
Initial page:
717
End page:
722
Authors:
Perez, O.;Valenzuela, C.;Delpon, E.;Tamargo, J.

Effects of lisinopril on cardiac contractility and ionic currents

1994 General Pharmacology
Volume:
25
Initial page:
825
End page:
832
Authors:
Valenzuela, C.;Perez, O.;Delpon, E.;Tamargo, J.

Effects of lisinopril on electromechanical properties and membrane currents in guinea-pig cardiac preparations

1993 British Journal of Pharmacology
Volume:
109
Initial page:
873
End page:
879
Authors:
Valenzuela, C.;Perez, O.;Casis, O.;Duarte, J.;Perez-Vizcaino, F.;Delpon, E.;Tamargo, J.

Electrophysiological effects of the combination of imipramine and desipramine in guinea pig papillary muscles

1993 Journal of Cardiovascular Pharmacology
Volume:
21
Initial page:
13
End page:
20
Authors:
Delpon, E.;Valenzuela, C.;Perez, O.;Tamargo, J.

Cardiac arrhythmias (III). Classification of antiarrhythmic drugs. Present status and clinical relevance for the cardiologists | ARRITMIAS CARDIACAS (III). CLASIFICACION DE LOS FARMACOS ANTIARRITMICOS EN LOS 90: UN ENFOQUE PARA EL CARDIOLOGO

1993 Revista Espanola de Cardiologia
Volume:
46
Initial page:
183
End page:
194
Authors:
Tamargo, J.;Valenzuela, C.;Delpon, E.

Antiarrhythmics: Classification, mechanism of action and therapeutical interest | ANTIARRITMICOS: CLASIFICACION, MODO DE ACTUACION E INTERES TERAPEUTICO

1993 Revista Clinica Espanola
Volume:
192
Initial page:
189
End page:
196
Authors:
Tamargo, J.;Delpon, E.;Valenzuela, C.;Perez, O.

Pharmacology of CRE-1087, a new antiarrhythmic drug

1992 Cardiovascular Drug Reviews
Volume:
10
Initial page:
307
End page:
322
Authors:
Delpon, E.;Valenzuela, C.;Perez, O.;Statkow, P.;Aguirre, D.;Cillero, J.;Tamargo, J.

Electrophysiological effects of CRE-1087 in guinea-pig ventricular muscles

1992 British Journal of Pharmacology
Volume:
107
Initial page:
515
End page:
520
Authors:
Delpon, E.;Valenzuela, C.;Perez, O.;Tamargo, J.

Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone

1991 Journal of Cardiovascular Pharmacology
Volume:
17
Initial page:
894
End page:
902
Authors:
Valenzuela, C.;Bennett, P.B.

Tonic and frequency-dependent V¿(max) block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles

1991 Naunyn-Schmiedeberg's Archives of Pharmacology
Volume:
343
Initial page:
638
End page:
644
Authors:
Delpon, E.;Valenzuela, C.;Carron, R.;Perez-Vizcaino, F.;Tamargo, J.

Electrophysiological effects of the combination of mexiletine and flecainide in guinea-pig ventricular fibres

1991 British Journal of Pharmacology
Volume:
103
Initial page:
1411
End page:
1416
Authors:
Delpon, E.;Valenzuela, C.;Tamargo, J.

Amiodarone: new concepts of its antiarrhythmic effects | AMIODARONE: NUEVOS CONCEPTOS DE SU ACCION ANTIARRITMICA

1990 Anales de Medicina Interna
Volume:
7
Initial page:
42
End page:
50
Authors:
Tamargo, J.;Valenzuela, C.;Delpon, E.

Tonic and frequency-dependent V(max) block induced by imipramine in guinea pig ventricular muscle fibers

1990 Journal of Cardiovascular Pharmacology
Volume:
15
Initial page:
414
End page:
420
Authors:
Delpon, E.;Valenzuela, C.;Tamargo, J.

Electrophysiological effects of E-3753, a new antiarrhythmic drug, in guinea-pig ventricular muscle

1989 British Journal of Pharmacology
Volume:
96
Initial page:
970
End page:
976
Authors:
Delpon, E.;Valenzuela, C.;Tamargo, J.

Electrophysiologic interactions between mexiletine and propafenone in guinea pig papillary muscles

1989 Journal of Cardiovascular Pharmacology
Volume:
14
Initial page:
351
End page:
357
Authors:
Valenzuela, C.;Delpon, E.;Tamargo, J.

Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle.

1989 Journal of Cardiovascular Pharmacology
Volume:
14
Initial page:
783
End page:
789
Authors:
Valenzuela, C.;Sanchez-Chapula, J.

Comparison of six new antidepressants on isolated rat atria.

1988 Arzneimittel-Forschung/Drug Research
Volume:
38
Initial page:
805
End page:
809
Authors:
MANZANARES J;VALENZUELA C;DELGADO C;TAMARGO J.

Comparative effects of oxodipine and nifedipine in the isolated guinea-pig heart.

1987 Archives Internationales de Pharmacodynamie et de Therapie
Volume:
288
Initial page:
186
End page:
199
Authors:
TEJERINA T;DELGADO C;VALENZUELA C;TAMARGO J.

Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres.

1987 British Journal of Pharmacology
Volume:
90
Initial page:
575
End page:
582
Authors:
DELGADO C;TAMARGO J;TEJERINA T;VALENZUELA C

Electrophysiological effects of 5-hydroxypropafenone on guinea-pig ventricular muscle-fibers.

1987 Journal of Cardiovascular Pharmacology
Volume:
10
Initial page:
523
End page:
529
Authors:
VALENZUELA C;DELGADO C;TAMARGO J

Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria

1986 British Journal of Pharmacology
Volume:
87
Initial page:
317
End page:
325
Authors:
Delgado C;Manzanares J;Tamargo J;Valenzuela C

Negative inotropic effect of somatostatin in guinea-pig atrial fibres

1985 British Journal of Pharmacology
Volume:
86
Initial page:
547
End page:
555
Authors:
Diez J;Tamargo J;Valenzuela C