Microtubule Dynamics

Microtubules provide essential mechanical support and drive key processes like cell division and intracellular transport. Our research explores how macromolecular machines mediating microtubule dynamics are regulated during rapid remodeling events, including cell division and immune synapse formation. This regulation involves complex protein-protein interactions, post-translational modifications, and conformational changes. We focus specifically on the γ-tubulin ring complex (γTuRC), the primary driver of microtubule nucleation. By studying these fundamental principles, we aim to provide insights into diseases linked to microtubule defects, such as immunodeficiencies, ciliopathies, and neurodevelopmental disorders. Ultimately, our work strives to lay the groundwork for novel therapeutic strategies that can precisely modulate microtubule dynamics for the treatment of diseases such as cancer.