GENETICS AND CELL BIOLOGY OF CANCER: T-CELL LYMPHOBLASTIC NEOPLASMS

Our focus is on T-cell lymphoblastic leukaemia/lymphoma (T-LBL and T-ALL), where we aim to identify new molecular biomarkers and develop more effective treatments. We integrate genomics, transcriptomics, and proteomics to uncover driver-molecular mechanisms. We found γ-secretase inhibitors' effectiveness depends on MYC gene dosage and revealed non-apoptotic functions of FADD protein in these neoplasms. Combined radiation regimens showed promise in tumor control. We're investigating dysregulated circular RNAs and ncRNAs in T-cell lymphoblastic neoplasms, aiming for personalized precision medicine. We've studied circRNA expression in thymocyte differentiation, providing insights into their role. Additionally, we developed an RNA-Flow FISH method for quantifying long lncRNAs, including those related to telomeres. This method has implications in both research and clinical diagnostics.