DYNAMIC AND RECYCLING OF THE TRANSCRIPTIONAL MACHINERY ACROSS MITOSIS

The research focuses on understanding how genetic information is read and translated into different cell types during development. This involves studying processes like transcription and mitosis, which are essential for cell diversity and growth. Transcription, the first step of reading DNA, is crucial for establishing gene expression patterns in different cell lineages. While mitosis ensures the correct number of cells, it also silences transcription temporarily. The lab aims to uncover the mechanisms behind restarting transcription after mitosis and how daughter cells remember and rewire their gene programs during development. They study RNA polymerase 2 and the Cohesin complex, exploring their roles in gene expression and developmental diseases. Through cell culture, genomics, CRISPR, and microscopy, they seek to understand how gene expression and cell division coordinate during development.