Point-of-care analytical device for rapid and multiplexed detection of biomarkers

Analytical device for rapid and multiplexed detection of biomarkers present in biological fluids. It incorporates a simple electrochemical detection approach based on an array of electrochemical cells with a paper device.

Market need: Rapid, multiplexed detection of biomarkers in biological fluids such as bacteria and virus proteins like the ones produced by SARS-Cov-2 infection, RNA, IgM and IgG antibodies and cytokines (IL-6. IL-8), is increasingly demanded for point-of-care diagnostics. There is a need for devices that allow multi-parametric or multisample analysis quickly, reliably, and with minimal material consumption, to meet the growing demands of biomedical testing in clinical and field environments.

Proposed solution: The device combines a reusable on-chip electrochemical transducer array with a disposable paper fluidic component in a compact plastic cartridge, enabling single-use measurements with minimal production of waste. The reduced size of the array enables the easy implementation with a compact multichannel paper strip device for performing quantitative multiplexed analysis. The incorporation of magnetic nanoparticles simplify sample pretreatment for rapid, multi-biomarker analysis. This scalable, point-of-care platform is offered for patent licensing, targeting industrial partners in the biomedical sector.

Competitive advantages

Multiplexed and simultaneous detection of biomarkers in biological fluids such as blood, serum, urine, saliva, nasopharyngeal and oropharyngeal specimens.
Low-cost and minimum material waste production per analysis. Reduced device size and reusable electrochemical cell array and a disposable fluidic component.
Compact and simple array of electrochemical transducers for multiplexed detection, suitable for the production of point-of-care devices.