Study of the pathophysiological role of LRP1 in the cardiovascular system. Molecular mechanisms involved in the modulation of LRP1 expression and function by risk factors in the cardiovascular system

Signal transduction through the Ras-ERK pathway and its role in cellular proliferation and survival, both in physiological and pathological conditions, cancer in particular.

Our group pioneered the molecular approach to the genus Brucella aiming to colaborate in the solution of of a local problem with health, economic and social implication. The interest of the group may be described as the study of the Biology of the genus Brucella, mainly of the inateraction of the bacteria with the eukaryotic host using methods of Molecular and cellular biology, high thoroughput methodology including genomics and transcriptomics. Among other aspects we will analyze: -The capability and consequences of erythritol metabolism in Brucella.

Our research group studies the implication of the serotonergic and cannabinoid systems, and the neurogenic and neuroplastic processes in the CNS to understand the etiopathogeny of neuropsychiatric disorders and the mechanism of action of the CNS-acting drugs. Specially, we focus in the study of pharmacological targets to develop new fast acting antidepressant drugs. Several methodological approaches are used: molecular, biochemical, cellular, morphological, pharmacology assays, animal models of psychiatric disorders as well as neuronal progenitors and brain organotopic cultures.

The research activities and interests of this group focus on the development of "ab initio" techniques for the the simulation of magnetic, electronic and transport properties of nano-scale objects, the search for novel effects and devices of interest in Nanomagnetism, Nanoelectronics and Nanoespintronics and the simulation of novel effects in micromagnetism in collaboration with experimental groups of the CINN.

The research carried out within this group focuses on the physico-chemical and mathematical study of the dynamics of the Earth System at different spatio-temporal scales, as well as that of other planetary bodies.

The Geodynamics, Tectonics and Associated Hazards Research Group focuses on several key areas of geoscience, addressing crucial aspects related to the Earth's dynamics and associated natural hazards.

The group is formed by four researchers from CSIC. The group leads on a larger group that includes personnel from CREAF at a full time forming a single group including 45 people working as researchers, technicians, pre- and postdocs with intereses that embrace global and functional ecology, global change, climate change, volatile organic compounds, biosphere-atmosphere interactions and remote sensing.

The ARAE (High-Energy Astrophysics and Robotic Astronomy) Group at IAA-CSIC has focused in multiwavelength observations of astrophysical objects and stellar population synthesis models, besides developing robotic astronomical observatories worldwide and astronomical instrumentation, leading the BOOTES Network of Robotic Telescopes worldwide. With more than 300 publications -with 6 in Science and 17 in Nature amongst them- and 3 patents and 1 utility model, the ARAE group leads target-of-opportunity programs at major observatories and is part of several international collaborations.

We're researching how eukaryotic systems regulate mRNA translation globally and specifically. We identify new elements in ribosomes and mRNAs, and activities of initiation factors (eIFs) in differential translation during cell proliferation and stress responses. We study the ES6S region in 40S ribosomal subunits, its role in mRNA entry and scanning in various species. Using SARS-CoV-2's nsp1 protein, we explore how base composition in 5' UTR and CDS regions impacts translation and mRNA stability in human cells.