MITOCHONDRIAL BIOLOGY IN IMMUNE MODULATION

Our group focuses on understanding the cellular and molecular mechanisms that control T-cell lineage commitment and differentiation in the human thymus. We aim to uncover how dysregulation of these mechanisms contributes to T-cell acute lymphoblastic leukemia (T-ALL), with the goal of identifying therapeutic targets. Our research primarily centers on the NOTCH1 pathway, a major driver of T-ALL. We have developed innovative models to study human T-ALL and have utilized this knowledge to develop targeted therapies, such as CAR-T cells and antibody-drug conjugates. Additionally, we explore the role of NOTCH1 signaling in thymus biology, highlighting its importance in thymus regeneration for improved T-cell production.