- Stage of development
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Under preclinical development
- Intellectual property
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Priority patent application filed
- Intended collaboration
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Licensing and/or co-development
- Contact
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Alfonso del ReyVice-presidency for Innovation and Transferadelrey@icmab.escomercializacion@csic.es
- Reference
-
CSIC/AF/028
Additional information
#Health
#Diagnostics
#Imaging
#Oncology
Fluorescent nanovesicles as a bioimaging tool
Ultra-bright fluorescent nanoparticles with Near-Infrared emission for non-invasive imaging and diagnostics.
- Market need
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NIR fluorescent dyes are powerful tools for fluorescence-guided surgery, sentinel lymph node mapping, tumour detection, vascular imaging and diagnosis. However, current NIR dyes have important limitations, including short circulation half-life, poor photostability, limited brightness and non-specific targeting.
Nanocarriers can help overcome these limitations, but existing fluorescent nanoparticles still face challenges such as poor particle-to-particle homogeneity, limited biocompatibility and insufficient robustness of optical and physicochemical properties during scale-up.
New fluorescent nanoparticles are needed to overcome these challenges.
- Proposed solution
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New NIR-emitting Quatsomes circumvent the above-mentioned challenges, while maintaining the advantages associated with NIR emitting dyes.
The nanoparticles display biocompatibility, high particle-to-particle homogeneity, long-term stability and can be functionalized with targeting compounds.
- Competitive advantages
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- Significant higher brightness over competitors.
- Tumour specificity.
- Long circulation half life.
- Scalable production under GMPs.
- Room temperature storage.