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Using mouse models involving gene modifications such as transgenics, knock-ins, and knockouts, we aim to investigate cellular plasticity within the…
The Drosophila wing originates from an epithelial tissue (wing imaginal disc), which growth and differentiation depends on the activity of conserved…
Our research focuses on cell-to-cell communication mechanisms and their role in development and diseases. We study how signaling molecules distribute…
Characterization of the development, composition and function of the renal filtration system and its pathological anomalies using animal models (…
To elucidate the stoichiometry of the TCR. Study the mechanisms of assembly and intracellular retention. Discern between the specific and redundant…
Glycosylation is a complex post-translational modification that generates diverse glycans, contributing to the functional diversity of proteins. Our…
Our group has demonstrated experience in the functional characterization of surface proteins on tumour, leukocytic and endothelial cells, that have…
Mechanisms of infected cell recognition and in vivo control of viral infections by CD8+ cytotoxic T lymphocytes and use in vaccine development.
Our research focuses on the role of TCFL5, a bHLH transcription factor, in colon cancer cells. Deletion of TCFL5 significantly reduces tumor…
There are many evidences for the involvement of lipid mediators such as prostanoids and cholesterol derivatives in the modulation of inflammatory and…