The focus of our research has been the PI3K/AKT/FOXO signaling which is considered as the most frequently activated pathway in cancer. FOXO is the major transcriptional effector of this signaling pathway and inactivated in many tumours. FOXO3a is the second most replicated gene associated with extreme human longevity.

Our group works in the areas of metal-free and transition metal catalyzed processes, electrochemistry and supramolecular organic chemistry. We are interested in developing new sustainable synthetic methodologies to access functional and complex structures in a controlled and selective fashion. These synthetic methods have been applied in the selective functionalization of drugs and bioactive molecules, as well as in the synthesis of natural products.

Our laboratory is interested in studying how different epigenetic features affect gene expression. We are especially interested in the mechanisms that regulate the accessibility to chromatin, as well as the methylation of DNA. To address these questions, we combine molecular biology, biochemistry and genomics.

The main aim of my research is understanding molecular mechanisms of functional innovation and complexity. We are interested in the evolutionary trajectories to biological innovations, being driven by either genomic or regulatory changes. This knowledge is relevant to the understanding of species diversification and emergence of biological complexity, but also it provide cornerstones to biotechnological (compound production under different biotic and abiotic stresses) and biomedical issues (oxidative stress, longevity, ...).

Our research activity focuses on the study of the effects of forest management and global change on the production, dynamics, and structure of forest ecosystems, from forestry crops to mature forests, the development of new monitoring techniques for these ecosystems, as well as provide scientific support to the National Forest Inventory

Research, development and innovation in emerging and transboundary infectious diseases with serious impact in animal and public health such as African swine fever (ASF), and other important epizootics, as well as emerging viral zoonoses such as West Nile virus fever / encephalitis, or West Nile (WN), Rift Valley fever (RVF) and Crimean Congo hemorrhagic fever, among others. In this group the Reference Laboratory of the European Union and the FAO Reference Center for African swine fever are located.

Study of the mechanisms of the innate and adaptive immune response of fish and how they are modified during infection with different pathogens. This knowledge leads to developments of long-lasting mass vaccination systems using specific adjuvants.

The "Effects of Environmental Contaminants" group studies the mechanisms underlying the toxicity of emerging pollutants (nanomaterials, endocrine disruptors, biocides or mycotoxins), as well as their bioaccumulation, particularly in fish. Two approaches are followed to reach this aim: in vitro assays in cell lines and in vivo assays, in aquatic organisms (algae, daphnia and fish). Cell assays study the short- and long-term effect on cell viability, sublethal effects, and substance internalization.

The research of our group focuses primarily on two key areas within Phytopathology and Plant Bacteriology. The first line of work is aimed at the identification and characterization of bacteria, with the purpose of developing useful tools for diagnosing plant diseases and identifying those capable of causing diseases in plants. By creating rapid and accurate diagnostic methods, we aim to facilitate early detection and control of these diseases, helping to reduce economic losses and promote more sustainable agricultural practices.

Our research focuses on the analysis of early embryonic development in vivo and in vitro in mammals, the understanding of mechanisms controlling embryo-maternal interactions (reproductive fluids, Extracellular Vesicles/Exosoms, Organoids, Assembloids etc), the study of factors responsible for infertility in dairy cows, and the development of strategies reducing embryonic losses and increasing pregnancy rates.