Study of the experimental conditions that will increase the frequency of gene targeting in human cells by testing different viral vectors and modifying the expression of key protein in the repair of DNA lesions by using fusion proteins and specific siRNAs. We will use the most effective methods to correct mutations in primary cells from patients with monogenic diseases, particularly certain primary immunodeficiencies.

Molecular genetics, genomics, transcriptomics and cell biology of thyroid cancer genesis, maintenance and progression, with especial emphasis on translation of multilevel genomic data obtained in the field of tumor dedifferentiation, invasion / metastases and therapy resistance. Identification of new molecular targets and diagnostic - prognostic - therapeutic algorithms, that may help clinicians on patient surveillance and mangement.

STUDY OF THE MECHANISMS THAT CONTROL CELL PLASTICITY AND MOVEMENTS DURING EMBRYONIC DEVELOPMENT AND IN ADULT PATHOLOGIES. The epithelial to mesenchymal transition (EMT) endows cells with migratory and invasive properties and is crucial during embryonic development, as the majority of adult tissues are the result of at least one round of EMT and the reverse process (MET). We found the first transcription factor able to induce EMT in embryos (Science, 1994) and its connection with cancer (Nat Cell Biol, 2000), and achondroplasia (Dev Cell, 1997).

Drosophila, Ultra-high-throughput screening, Cancer Genes and Mechanisms, Anti-cancer Responses, Genetic Robustness, Buffering, and Healthy Ageing,

Most metazoans are bilaterally symmetric and many features of mature neural function including the interpretation of sensory information and the coordination of locomotion depend on the coherent communication between the two brain hemispheres. In order to integrate sensory information from both sides of the body and then elaborate a coordinated response, the nervous system requires both axons crossing at the midline and axons remaining in the ipsilateral side of the brain.

Our research team runs several related projects studying the cellular and molecular mechanisms involved in the development of axonal connections in the brain. In particular, our aim is to uncover the principles underlying thalamocortical axonal wiring, maintenance and ultimately the rewiring of connections, through an integrated and innovative experimental programme.

Analysis of the cellular and molecular mechanisms controlling the development of the most anterior region of the brain, the telencephalon

TO BE LOADED SOON

Our general aim is to understand the molecular mechanisms that control the generation of the different neuron subtypes of the nervous system