The Castaño group is devoted to the advancement of the numerica methods for cryo electron tomography, including all aspects of the pipeline: alignment, reconstruction, particle location, subtomogram averaging and classification. This includes exploring protocols for cooperative use of further imaging techniques from Structural and Cellular biology (as superresolution light microscopy) towards the integration of information on multiple scales in space and time, aiming at the completion of mechanistic studies of key life processes. The group is commited to the production of robust, user-friendl

Our research explores the interface between chemical biology, medicinal chemistry and supramolecular chemistry. We use modern analytical techniques to study dynamic combinatorial libraries: dynamic networks of interchanging chemical species. We apply these dynamic networks as a hit-identification tool in drug discovery to gain insight into diseases’ etiology and study the properties derived from the molecular networks in the emerging field of systems chemistry to mimic functions encountered in Nature.

Dr. Liesa did his PhD at the University of Barcelona under the supervision of Dr. Antonio Zorzano, on the role and regulation of mitochondrial dynamics in muscle. In 2009, Dr. Liesa was awarded a fellowship from Fundación Ramon Areces to perform his post-doctoral research at Boston University. In 2013, Dr. Liesa became a junior group leader at Boston University and in 2015 was recruited by the Department of Medicine and the David Geffen School of Medicine at UCLA as an Assistant Professor to lead his lab in the new Metabolism Theme, where he was promoted to Associate Professor. Dr.

Analytical NutriAgeing research group specializes in developing new analytical tools and methods based on mass spectrometry for the analysis of molecules, employing omics approaches, with a particular emphasis on metabolomics and the design of related methodologies.

Our group is interested in studying the molecular architecture of large multisubunit complexes involved in DNA/RNA-associated functions, with special emphasis on the interaction between retrotransposons and host elements. Traditionally considered "junk" regions of the genome, mobile elements have recently emerged as key players in the development and progression of several diseases, including neurological disorders and cancer. In our laboratory, we intend to study the relevance of these elements at the molecular level through biophysical, biochemical and structural biology tools.

Our research focuses on identifying genes associated with psychiatric disorders. We use genomic techniques like sequencing to study the genetic basis of conditions like autism, bipolar disorder, and schizophrenia. We analyze both common and rare genetic variants to understand their roles in these disorders. Our work has led to the discovery of several susceptibility genes and pathways related to bipolar disorder. We also collaborate with international efforts to study the genetics of psychiatric disorders and their response to treatments.

Our lab focuses on studying the metabolic features of aggressive lymphomas with poor outcomes, specifically those involving MYC and BCL2 alterations. We aim to identify new metabolic vulnerabilities in these tumors using advanced tools and patient samples, potentially leading to targeted therapies beyond current options.

This research group is focused in the replicative sequences that have colonised and multiply within the human genome, known as mobile genetic elements (MGEs) or mobile DNA. MGEs’ replicative activity led to an accumulation of copies that accounts for ~50% of the human genome. They cause insertional mutagenesis, leading to an increase of genetic diversity and occasionally responsible of spontaneous genetic disease and cancer. Epigenetic silencing is known to minimise their deleterious impact, although the mechanism responsible for driving this silencing to active MGEs is largely unknown.

Our research team focuses on the study of the tissue remodelling that occurs during the development, progression and resolution of chronic diseases, with a special emphasis on fibrosis and cancer. Tissue remodelling involves both the cellular components of the tissue and the extracellular matrix (ECM) in a complex interplay where both send signals to each other, triggering important biological events such as cell death/proliferation, ECM synthesis/degradation, regeneration and inflammation among others.