Skip to main content
 

Structural Plasticity of Metamorphic Proteins

Structural Plasticity of Metamorphic Proteins


PLASTIMORF leverages cutting-edge structural, orthogonal and translational techniques to unravel mechanisms behind protein structural changes that lead to a prion-like gain-of-function (Structural Biology of Prionoids). We study metamorphic proteins that defy AI-based structural prediction methods. Such proteins adopt alternative conformations in response to specific stimuli, leading to multimerization into biomolecular condensates or amyloid aggregates.
Main specialization

SYNTHESIS AND BIOMEDICAL APPLICATIONS

SYNTHESIS AND BIOMEDICAL APPLICATIONS


Our research is dedicated to the design, synthesis, and development of novel pharmacological agents and chemical probes for therapeutic and diagnostic applications across diverse pathological conditions. We integrate advanced methodologies in organic synthesis with state-of-the-art strategies and concepts from medicinal chemistry to generate compounds and molecular tools with translational potential in biomedicine.
Main specialization

ANIMAL DEMOGRAPHY AND ECOLOGY

ANIMAL DEMOGRAPHY AND ECOLOGY


The group focuses on understanding the demography of wildlife populations in space and time, with relevance to applied ecology and conservation. Using long-term individual-based capture–mark–recapture data, individual animal movement data and community level monitoring, the team harnesses advanced statistical modelling and conservation planning tools, from local to global scales.
Main specialization

Water and Crops

Water and Crops


Research group dedicated to studying Mediterranean agro-ecosystems under semi-arid climate conditions. We conduct applied research aimed at solving real problems in agriculture by optimizing water, soil, and nutrient management using various agronomic practices. Thanks to an innovative approach and our expertise in irrigation technologies and remote sensing, our goal is to improve crop quality in vegetable, fruit tree and vine crops while ensuring the economic and environmental sustainability of agricultural systems.
Main specialization