Pre-mRNA processing or splicing is an essential step of eukaryotic gene expression, where the spliceosome removes introns and exons are sequentially joined . A high proportion of genetic diseases are associated to splicing anomalies of responsible genes. Our main interest is focused on the study of the correlation between aberrant splicing of tumor suppressor genes and susceptibility to breast/ ovarian cancer (BC/OC), as well as the study of the regulatory mechanisms of this process.

We are an interdisciplinary research group combining biophysical, cell biology, biochemistry and molecular biology methodologies. Two are our main research focuses: from one side, we are interested in the study of the molecular mechanisms that underlie protein-protein and protein-membrane interactions, using as model system bacterial toxins, in particular, the adenylate cyclase toxin, which are essential virulence factors produced by different bacterial pathogens (e.g. Bordetella pertussis, Escherichia coli, ...).

Among ionic channels, those that are potassium selective are, by far, the most diverse group. They play a key role in processes such as immune response, cell differentiation, excitability and cell death, among others. More than 60 genes for potassium channels are known in the human genome, which together with the fact that up to four different subunits can combine to form a channel, means that there are a large numbers of variants.

The research interest of the group is focused in the study of cardiovascular disease, metabolism, atherosclerosis, atherothrombosis and the ischemic syndromes. 1. Basic Science . LRP family proteins in chronic diseases. . Molecular determinants of cardiovascular disease in obesity. . Identification and characterization of transcription factors and genetic targets. Role of HDL and LDL. . Vascular impact of ischemia and angiogenesis in heart disease. Cell therapy. 2. Translational Research in Collaboration with Clinical Groups . Familial hypercholesterolemia and its impact. .

The major research activity of this group addresses the study of the vascular biology as well as the cellular and molecular mechanisms involved in coronary artery disease, abdominal aortic aneurysm (AAA) and cardiac remodeling. The group analyzes the role of the NR4A subfamily of nuclear receptors, in particular NOR-1 (NR4A3), in those pathologies by using multidisciplinary and highly translational approaches.

Our group has been largely researched on bacterial conjugation using biochemical, structural, evolutionary and genetic approaches.

Our group is developing research projects dealing with four subjects: a)Functions of the transcription factors MYC, MXD and CTCF in cancer and cell differentiation. We are studying this involvement using hematopoietic differentiation (myeloerythroid cell line) or neuronal models, as well as their implication in leukemia and lymphoma.

Our goal is to understand the cellular and molecular basis of embryonic development. Our main interest is how the interactions between the different signaling pathways control morphogenesis

This group focuses its scientific activity on the study of physics in mesoscopic hybrid nanostructures based on the following types: Superconducting / Magnetic Magnetic / Non Magnetic Magnetic / Magnetic Magnetic / Semiconductor Proximity and interface effects in ferromagnetic/semiconductor (F/SM) hybrid nanostructures Resonance effects in noble metal/ferromagnet (NM/F) hybrid nanostructures and multilayers.

The mission of the group is to improve the physical understanding of the climate system, its evolution, impacts and the mechanisms responsible for climate variability and change at different temporal and spatial scales, with the vision of advancing the multiple dimensions of climate change and contributing to current societal challenges. The group's activity is summarised in two lines of research based on experimentation and modelling with the aim of providing an integrated approach to the functioning of the climate system.