The research focuses on understanding how genetic information is read and translated into different cell types during development. This involves studying processes like transcription and mitosis, which are essential for cell diversity and growth. Transcription, the first step of reading DNA, is crucial for establishing gene expression patterns in different cell lineages. While mitosis ensures the correct number of cells, it also silences transcription temporarily.

We investigate the mechanisms that control the spatio-temporal expression of genes operating in brain cortex development by using human brain organoids (self-organized 3D cultures derived from pluripotent stem cells that recapitulate brain structure development and inner organization) as a model system.

The Epigenetics & Cellular Senescence lab is interested in understanding the basic mechanisms regulating cellular senescence and its influence on the microenvironment

Telomeres are crucial components of our genome, protecting it from deterioration. They consist of repetitive DNA sequences and specialized proteins at the ends of chromosomes. Telomere fusions, where chromosome ends join, are important in cancer and regeneration. Our group studies telomere fusions in cancer, finding varied rates and patterns among different cancers, including links to telomere lengthening pathways. We've detected these fusions in blood, offering potential for early cancer detection.

Our research focuses on developing new phage-assisted accelerated evolution techniques for engineering proteins, targeting the re-engineering of gene regulation, and phages for innovative antimicrobial development. Additionally, we explore the creation of neuromorphic gene circuits in bacteria, aiming to develop new forms of living artificial intelligence. More information is available at: http://jaramillolab.org

Our research focus is to enhance immune resilience against inflammation, cellular senescence, and age-related diseases. We have demonstrated that mitochondrial dysfunction in T cells mimics aging and leads to widespread health deterioration (Science, 2020). We have also identified molecular mechanisms by which aged T cells contribute to age-related diseases (Cell Metabolism 2021; Nature Rev Immunol, 2022). Additionally, we propose therapies to reverse aortic aneurysms and improve mitochondrial metabolism (Circulation, 2021; Atherosclerosis, Thrombosis Vascular Biology, 2022; Br J Pharmacol.

The Mediterranean Climate Change Group (GCC) has as its main objective the study of the effects that climate change could have on the Mediterranean Sea and its ecosystems, paying particular attention to the waters surrounding the Spanish coasts, Including the Balearic Islands. The studies carried out by this group are multidisciplinary in nature, since they aim to understand the effects on physical, chemical and biological variables.