Telomeres in cancer and regeneration

Telomeres are crucial components of our genome, protecting it from deterioration. They consist of repetitive DNA sequences and specialized proteins at the ends of chromosomes. Telomere fusions, where chromosome ends join, are important in cancer and regeneration. Our group studies telomere fusions in cancer, finding varied rates and patterns among different cancers, including links to telomere lengthening pathways. We've detected these fusions in blood, offering potential for early cancer detection. Additionally, we explore how telomere fusions relate to cardiomyocyte (heart muscle cell) maturation and regeneration. Polyploidization, an increase in chromosome sets, is common in mature cardiomyocytes, but the mechanisms behind it remain unclear. We found chromosome bridges in dividing cardiomyocytes and a link between telomere fusions and polyploidization. Understanding telomere fusions' roles could lead to targeted therapies in cancer and heart regeneration.