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Functional Epi-Genomics of Aging and Alzheimer's Disease

Functional Epi-Genomics of Aging and Alzheimer's Disease


Our laboratory investigates the molecular underpinnings of age-related cognitive decline and neurodegeneration, with a particular interest in Alzheimer’s disease (AD). We hypothesize that genetics, epigenetics, and the interaction of both – “neuro-epi-genetics” –, have long-lasting effects on brain function. To tackle this hypothesis, we use mouse models and human samples, and combine molecular and behavioral neuroscience with state-of-the-art single-cell, next generation sequencing (NGS), bioinformatic tools and epi-genetic editing.
Main specialization

CHEM.PTML

CHEM.PTML


CHEM.PTML algorithms/software, consulting/counseling, and training activities are focused to reduce partners experimental research and/or production costs in terms of material resources, laboratory animals, and time. The principal tools used in our group are the result of combining Cheminformatics, Artificial Intelligence (AI), Machine Learning (ML) algorithms. We put special emphasis on the use of Perturbation-Theory Machine Learning (PTML) method developed and published by our group.
Main specialization

Assembly of Materials and Surface Modification

Assembly of Materials and Surface Modification


ENMA¿s group (Assembly of Materials and Surface Modification) has wide experience in the assembly of organic, inorganic or hybrid materials using the Langmuir-Blodgett (LB), self-assembly (SA), electrografting or spin-coating techniques and their characterization by spectroscopic, microscopic or electrochemical techniques, as well as in the modification of surfaces through physicochemical processes ((super)-hydrophobicity / hydrophilicity), or formation of nanostructures.
Main specialization

Laser, Energy and Advanced Materials

Laser, Energy and Advanced Materials


LEMA research group activities include several research lines based on the application of different laser technologies to modify materials. These include development of new materials with technological interest in different industrial sectors. The latter are related with higher efficiency and cleaner energy and based on environmentally respectful new processing techniques.
Main specialization

Hybrid materials and their structuration (HYMAT)

Hybrid materials and their structuration (HYMAT)


HYMAT is a multidisciplinar group formed by chemists and physicists from INMA, with a wide expertise in the synthesis and physics of magnetic materials, and in the nanostructuration of diverse types of materials (carbon-based materials, perovskites, MOFs, magnetic nanoparticles, polymer-nanoparticle hybrid materials). Its activity involves the elaboration of hybrid materials and/or devices, in the frame of the three following research lines: A) Molecular magnetic materials for ICT applications B) Magnetic hyperthermia C) Energy
Main specialization

Nanoscopy on Low Dimensional Materials (NLDM)

Nanoscopy on Low Dimensional Materials (NLDM)


The research interest of the Nanoscopy on Low Dimensional Materials (NLDM) group is mainly focused on the study of the atomic structure and configuration, as well as the physical (electronic, optical, vibrational, mechanical) properties of low-dimensional nanomaterials based on carbon, boron and nitrogen, transition metal dichalcogenides as well as other nano-structures (in particular, metallic nano-objects for plasmonic/photonic interest).
Main specialization

CO2 Conversion and Circular Chemistry

CO2 Conversion and Circular Chemistry


The group performs experimental studies concerning environmental and energy-related catalysis and chemical processes, going from fundamentals to applied research. The main unifying topics of this broad area are: (1) The development of new processes that convert residual streams into chemicals, fuels and other products, considering a waste as a resource (2) The use of renewable energy sources. The research aims to understand the key parameters that control the reactivity and selectivity, following a rational design strategy to optimize catalysts.
Main specialization