Matrix Metalloproteinases in Angiogenesis and Inflammation
Matrix Metalloproteinases in Angiogenesis and Inflammation
Our group is interested in elucidating the cellular principles and molecular mechanisms that govern vascular and immune responses during inflammation and how these can contribute to tissue repair. We focus on the actions of membrane-type matrix metalloproteinases (MT-MMPs), a subfamily of proteases that can modify dynamically the extracellular matrix and the activity of soluble and membrane proteins, and particularly in their impact on the behavior of endothelial and smooth muscle cells, and of monocytes/macrophages.
Main specialization