Characterization of the development, composition and function of the renal filtration system and its pathological anomalies using animal models (Drosophila and zebra fish).

To elucidate the stoichiometry of the TCR. Study the mechanisms of assembly and intracellular retention. Discern between the specific and redundant roles of each of the TCR subunits.

Glycosylation is a complex post-translational modification that generates diverse glycans, contributing to the functional diversity of proteins. Our group has focused on analyzing the N-glycome using a novel platform to study disease markers. We've collected well-characterized samples from Chagas disease, visceral leishmaniasis, and neurocysticercosis. By analyzing individual glycomic profiles, we've identified markers of treatment efficacy and disease progression.

Our group has demonstrated experience in the functional characterization of surface proteins on tumour, leukocytic and endothelial cells, that have implication in the processes of adhesion, migration, angiogenesis and tumoral dissemination.

Mechanisms of infected cell recognition and in vivo control of viral infections by CD8+ cytotoxic T lymphocytes and use in vaccine development.

Our research focuses on the role of TCFL5, a bHLH transcription factor, in colon cancer cells. Deletion of TCFL5 significantly reduces tumor properties. Two major isoforms, TCFL5_E1/E8 and TCFL5_E2b/E8, have distinct functions. TCFL5_E1/E8 regulates anti-apoptotic genes like BCL2, while TCFL5_E2b/E8 controls pluripotency markers. We identified genes regulated by these isoforms and their roles in leukemia and lymphopoiesis. TCFL5_E2b/E8 is associated with severity in lymphoma and myeloma. Tcfl5 deficiency impairs germinal center formation and B cell differentiation.

There are many evidences for the involvement of lipid mediators such as prostanoids and cholesterol derivatives in the modulation of inflammatory and cardiovascular pathophysiology. Prostanoids have important roles in physiological processes such as renal and vascular homeostasis, as well as having a central role in the inflammatory process.

The kinase GRK2 as a central node in cell signaling networks. Study of its interactome and implications in cardiovascular, inflammatory, diabetes/obesity, or tumor progression pathologies.

Our interest is the identification of the molecular regulators that control the physiological and pathological development of T and non-T (mainly dendritic) cells in the human thymus. Using loss and gain of function genetic approaches, functional assays and in vivo models of hematopoietic reconstitution in humanized mice, we have focused on the Notch1 signaling pathway, analyzing the spatio-temporal regulation of its ligands in the thymus and its role in the physiology of intrathymic T-cell development.

We are interested in understanding how viruses evade the host immune response. We are characterizing herpesvirus and poxvirus proteins that interact with interferons, cytokines or chemokines, and modulate their activity. The contribution of viral cytokine receptors to pathogenesis is being addressed in mouse models of infection.