Subcellular architecture and Neurodegeneration

Our group is interested in the study of subcellular architecture and in exploring the structural alterations that occur in pathological conditions in neurodegenerative diseases, with a special focus on Huntington's Disease as a model. Our hypothesis is that the maintenance of subcellular architecture is essential to preserve cellular homeostasis. The analysis of these alterations can contribute to understanding the pathophysiological bases of the disease, serve as a biomarker of disease progression, aid in the identification of therapeutic targets and to evaluate the effectiveness of future treatments. To do this, we use advanced methods for preparing samples, cells and tissues, by vitrification (high-pressure freezing) and structural studies using advanced 3D electron microscopy techniques (ET and FIB-SEM). 1. Development of correlative microscopy methods with molecular resolution. 2. Explore the relevance of ribosome stalling and specialization in Huntington's disease.