Structure of macromolecular targets unit

Research in my laboratory is focused on understanding the molecular mechanisms and cellular functions of proteins and how their defects can lead to disease. We are particularly interested in explaining protein malfunction, in identifying disease-causing variants, and in helping to find new therapeutic strategies to amend the activity of the faulty proteins. My group’s approach itegrates biochemical and biophysical methods to define the structure, function and evolution of these macromolecular targets. Our toolbox combines protein engineering, enzymology, X-ray crystallography, electron microscopy, molecular dynamics, cellular assays and genome editing, among other approaches.