Structural Biology of Ribonucleoprotein Assemblies (RNPSTRUC)

Structural biology group studying proteins involved in RNA cell cycle. We study the structure of RNA binding proteins (RBPs) and their interactions at structural detail using NMR and biophysical techniques (ITC, DLS, MALS, FA) and with other structural techniques (X-ray, CryoEM, SAXS) in close collaboration with other CSIC groups. We study RBPs part of the RNA life cycle during the maturation of mRNPs (Gbp2, Hrb1 Nrd1, Nab3, Hrp1 or CstF64), or regulation of translation and stress response (eIF4G, Pab1, Pub1). More recently we focus our interest in RBPs involved in human diseases (Gemin-5 and hnRNP A1) and viral nucleocapsids (SARS-CoV, MERS, etc), being their RNA binding activities and other biophysical properties (e.g. formation of protein condensates) key on the onset and development of the diseases.